The Role of Inflammation in the Pathophysiology of Depression and Suicidal Behavior: Implications for Treatment.

Humans Suicidal Ideation Depression Inflammation Mental Disorders
Biomarkers Depression Inflammation Neuro-inflammation Suicidal behavior Suicide Treatment

Journal

The Medical clinics of North America
ISSN: 1557-9859
Titre abrégé: Med Clin North Am
Pays: United States
ID NLM: 2985236R

Informations de publication

Date de publication:
Jan 2023
Historique:
entrez: 19 11 2022
pubmed: 20 11 2022
medline: 23 11 2022
Statut: ppublish

Résumé

Depression and suicidal behavior are 2 complex psychiatric conditions of significant public health concerns due to their debilitating nature. The need to enhance contemporary treatments and preventative approaches for these illnesses not only calls for distillation of current views on their pathogenesis but also provides an impetus for further elucidation of their novel etiological determinants. In this regard, inflammation has recently been recognized as a potentially important contributor to the development of depression and suicidal behavior. This review highlights key evidence that supports the presence of dysregulated neurometabolic and immunologic signaling and abnormal interaction with microbial species as putative etiological hallmarks of inflammation in depression as well as their contribution to the development of suicidal behavior. Furthermore, therapeutic insights addressing candidate mechanisms of pathological inflammation in these disorders are proposed.

Identifiants

DOI: 10.1016/j.mcna.2022.09.001 PMID: 36402492
pubmed: 36402492
pii: S0025-7125(22)00116-X
doi: 10.1016/j.mcna.2022.09.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-29

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Gianluca Serafini (G)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy. Electronic address: gianluca.serafini@unige.it.

Alessandra Costanza (A)

Department of Psychiatry, Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland; Department of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), Lugano, Switzerland.

Andrea Aguglia (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy.

Andrea Amerio (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy.

Alice Trabucco (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy.

Andrea Escelsior (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy.

Leo Sher (L)

James J. Peters VA Medical Center, Bronx, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, New York, NY, USA.

Mario Amore (M)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health DINOGMI, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Inflammation in the...
questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Suicide › Idéation suicidaire › The Role of Inflammation in the...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › The Role of Inflammation in the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The Role of Inflammation in the...
questionsmedicales.fr › Troubles mentaux › The Role of Inflammation in the...