De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019.
Alloantibody
COVID-19
M-antigen
Transfusion
Journal
Journal of infection and public health
ISSN: 1876-035X
Titre abrégé: J Infect Public Health
Pays: England
ID NLM: 101487384
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
26
01
2022
revised:
25
10
2022
accepted:
27
10
2022
pubmed:
21
11
2022
medline:
7
12
2022
entrez:
20
11
2022
Statut:
ppublish
Résumé
The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.
Identifiants
pubmed: 36403401
pii: S1876-0341(22)00290-8
doi: 10.1016/j.jiph.2022.10.025
pmc: PMC9628129
pii:
doi:
Substances chimiques
Blood Group Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455-1458Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Conflict of interest Authors have no competing interest to disclose.
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