Exposure to diesel exhaust alters the functional metagenomic composition of the airway microbiome in former smokers.

Humans Vehicle Emissions / toxicity Smokers Air Pollution / analysis Metagenome Microbiota Air Pollutants / analysis
Air pollution Chronic obstructive pulmonary disease Diesel exhaust Former smokers Human airway microbiome Metabolic functions

Journal

Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621

Informations de publication

Date de publication:
01 01 2023
Historique:
received: 06 09 2022
revised: 01 11 2022
accepted: 14 11 2022
pubmed: 21 11 2022
medline: 7 2 2023
entrez: 20 11 2022
Statut: ppublish

Résumé

The lung microbiome plays a crucial role in airway homeostasis, yet we know little about the effects of exposures such as air pollution therein. We conducted a controlled human exposure study to assess the impact of diesel exhaust (DE) on the human airway microbiome. Twenty-four participants (former smokers with mild to moderate COPD (N = 9), healthy former smokers (N = 7), and control healthy never smokers (N = 8)) were exposed to DE (300 μg/m

Identifiants

DOI: 10.1016/j.envres.2022.114826 PMID: 36403657
pubmed: 36403657
pii: S0013-9351(22)02153-3
doi: 10.1016/j.envres.2022.114826
pii:
doi:

Substances chimiques

Vehicle Emissions 0
Air Pollutants 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114826

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

Auteurs

Illiassou Hamidou Soumana (I)

Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Min Hyung Ryu (MH)

Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Fernando Studart Leitao Filho (FS)

Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

Julia Yang (J)

Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

Juma Orach (J)

Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Corey Nislow (C)

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

Janice M Leung (JM)

Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

Christopher Francis Rider (CF)

Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Christopher Carlsten (C)

Air Pollution Exposure Laboratory, Vancouver Coastal Health Research Institute, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address: carlsten@mail.ubc.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exposure to diesel exhaust alters the...
questionsmedicales.fr › Mélanges complexes › Emissions des véhicules › Exposure to diesel exhaust alters the...
questionsmedicales.fr › Personnes › Fumeurs › Exposure to diesel exhaust alters the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Exposure to diesel exhaust alters the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Métagénome › Exposure to diesel exhaust alters the...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Exposure to diesel exhaust alters the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Exposure to diesel exhaust alters the...