Humans pIKK-up NLRP3 to skip NEK7.

Humans Mice Animals NLR Family, Pyrin Domain-Containing 3 Protein / metabolism NIMA-Related Kinases / genetics Mice, Inbred C57BL Inflammasomes / metabolism Protein Serine-Threonine Kinases
IKKβ NEK7 NLRP3 TAK1 cell death inflammasome

Journal

Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032

Informations de publication

Date de publication:
12 2022
Historique:
received: 07 10 2022
accepted: 14 10 2022
pubmed: 21 11 2022
medline: 29 11 2022
entrez: 20 11 2022
Statut: ppublish

Résumé

NLRP3 inflammasome regulation is essential for controlling cell death and inflammation. Mechanistic studies in murine cells suggest a two-step model of priming and activation with an indispensable role for NEK7. However, in a recent article in Immunity, Schmacke et al. report that, in humans, transcription-independent NLRP3 activation occurs by circumventing NEK7 via IKKβ.

Identifiants

DOI: 10.1016/j.it.2022.10.007 PMID: 36404209
pubmed: 36404209
pii: S1471-4906(22)00228-9
doi: 10.1016/j.it.2022.10.007
pii:
doi:

Substances chimiques

NLR Family, Pyrin Domain-Containing 3 Protein 0
NIMA-Related Kinases EC 2.7.11.1
Inflammasomes 0
Protein Serine-Threonine Kinases EC 2.7.11.1
NEK7 protein, human EC 2.7.11.1
Nlrp3 protein, mouse 0
Nek7 protein, mouse EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

947-949

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests T.-D.K. is a consultant for Pfizer.

Auteurs

R K Subbarao Malireddi (RKS)

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Thirumala-Devi Kanneganti (TD)

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: Thirumala-Devi.Kanneganti@StJude.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Eucaryotes › Animaux › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Kinases apparentées à NIMA › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Humans pIKK-up NLRP3 to skip NEK7.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Humans pIKK-up NLRP3 to skip NEK7.