Ceramides and Acute Kidney Injury.
Acute kidney injury
ceramides
sphingolipids
Journal
Seminars in nephrology
ISSN: 1558-4488
Titre abrégé: Semin Nephrol
Pays: United States
ID NLM: 8110298
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
pubmed:
21
11
2022
medline:
11
1
2023
entrez:
20
11
2022
Statut:
ppublish
Résumé
Altered lipid metabolism is a characteristic feature and potential driving factor of acute kidney injury (AKI). Of the lipids that accumulate in injured renal tissues, ceramides are potent regulators of metabolism and cell fate. Up-regulation of ceramide synthesis is a common feature shared across several AKI etiologies in vitro and in vivo. Furthermore, ceramide accumulation is an early event in the natural history of AKI that precedes cell death and organ dysfunction. Emerging evidence suggests that inhibition of ceramide accumulation may improve renal outcomes in several models of AKI. This review examines the landscape of ceramide metabolism and regulation in the healthy and injured kidney. Furthermore, we discuss the body of literature regarding ceramides as therapeutic targets for AKI and consider potential mechanisms by which ceramides drive kidney pathogenesis.
Identifiants
pubmed: 36404212
pii: S0270-9295(22)00063-8
doi: 10.1016/j.semnephrol.2022.10.007
pmc: PMC9907354
mid: NIHMS1868310
pii:
doi:
Substances chimiques
Ceramides
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
151281Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK115824
Pays : United States
Organisme : NIDDK NIH HHS
ID : R44 DK116450
Pays : United States
Organisme : NIDDK NIH HHS
ID : R43 DK116450
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA272529
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK131609
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK130296
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112826
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122001
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK091317
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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