Neutrophils are gatekeepers of mucosal immunity.
gastrointestinal
lung
mucosal immunity
neutropenia
neutrophils
oral
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pmc-release:
01
03
2024
medline:
29
3
2023
pubmed:
22
11
2022
entrez:
21
11
2022
Statut:
ppublish
Résumé
Mucosal tissues are constantly exposed to the outside environment. They receive signals from the commensal microbiome and tissue-specific triggers including alimentary and airborne elements and are tasked to maintain balance in the absence of inflammation and infection. Here, we present neutrophils as sentinel cells in mucosal immunity. We discuss the roles of neutrophils in mucosal homeostasis and overview clinical susceptibilities in patients with neutrophil defects. Finally, we present concepts related to specification of neutrophil responses within specific mucosal tissue microenvironments.
Identifiants
pubmed: 36404627
doi: 10.1111/imr.13171
pmc: PMC10496120
mid: NIHMS1928127
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-141Subventions
Organisme : NIDCR NIH HHS
ID : R00 DE030124
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DE000736
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
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