Fast-forwarding evolution-Accelerated adaptation in a proofreading-deficient hypermutator herpesvirus.
DNA polymerase
Marek’s Disease Virus
adaptation
hypermutation
polymerase mutant
proofreading deficient
Journal
Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
06
2022
revised:
18
08
2022
accepted:
13
10
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
22
11
2022
Statut:
epublish
Résumé
Evolution relies on the availability of genetic diversity for fitness-based selection. However, most deoxyribonucleic acid (DNA) viruses employ DNA polymerases (Pol) capable of exonucleolytic proofreading to limit mutation rates during DNA replication. The relative genetic stability produced by high-fidelity genome replication can make studying DNA virus adaptation and evolution an intensive endeavor, especially in slowly replicating viruses. Here, we present a proofreading-impaired Pol mutant (Y547S) of Marek's disease virus that exhibits a hypermutator phenotype while maintaining unimpaired growth
Identifiants
pubmed: 36405341
doi: 10.1093/ve/veac099
pii: veac099
pmc: PMC9671156
doi:
Types de publication
Journal Article
Langues
eng
Pagination
veac099Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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