The effects of selenium supplementation on inflammatory markers in critically ill patients.

Critical illness Inflammation Oxidative stress Selenium Supplemtation

Journal

SN applied sciences
ISSN: 2523-3971
Titre abrégé: SN Appl Sci
Pays: Switzerland
ID NLM: 101763400

Informations de publication

Date de publication:
2022
Historique:
received: 02 07 2022
accepted: 19 10 2022
entrez: 21 11 2022
pubmed: 22 11 2022
medline: 22 11 2022
Statut: ppublish

Résumé

Low serum selenium (Se) levels have been shown in critical illness, which is associated with poor clinical outcomes and a higher mortality rate. Se plays an important role in inflammation and oxidative stress. Since the overproduction of inflammatory cytokines and increased oxidative stress is a major component of critical illnesses, its supplementation has been demonstrated to have promising effects on critically ill patients. This study aims to review the evidence regarding the effects of Se supplementation on inflammatory and oxidative markers in critically ill patients. The literature review highlights alterations of inflammatory markers, including procalcitonin, leukocyte count, albumin, prealbumin, C-reactive protein (CRP), inflammatory cytokines, and cholesterol following Se supplementation in critically ill patients. Besides, the antioxidant properties of Se due to its presence in the structure of several selenoenzymes have been reported. Low serum Se level have been shown in critical illness, which is associated with poor clinical outcome and higher mortality rate.Se plays an important role in inflammation and oxidative stress.Se supplementation can have promising effects by alterations of inflammatory markers and its antioxidant properties for critically ill patients.

Identifiants

pubmed: 36405547
doi: 10.1007/s42452-022-05208-4
pii: 5208
pmc: PMC9643959
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

326

Informations de copyright

© The Author(s) 2022.

Déclaration de conflit d'intérêts

Conflict of interestThe authors declare that they have no conflict of interest.

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Auteurs

Ata Mahmoodpoor (A)

Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Elnaz Faramarzi (E)

Liver and Gastrointestinal Diseases Research Center, Clinical Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Anita Reyhanifard (A)

Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Ali Shamekh (A)

Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Saba Nikanfar (S)

Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Akbar Azizi-Zeinalhajlou (A)

Research Center of Psychiatry and Behavioral Sciences, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Sarvin Sanaie (S)

Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Classifications MeSH