Adjuvants influence the maturation of VRC01-like antibodies during immunization.
Biological sciences
Immune response
Immunology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
received:
27
06
2022
revised:
26
08
2022
accepted:
26
10
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
22
11
2022
Statut:
epublish
Résumé
Once naive B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for the full maturation of VRC01-class antibodies. Here, we examined whether and how three adjuvants, Poly(I:C), GLA-LSQ, or Rehydragel, that activate different pathways of the innate immune system, influence the rate and type of somatic mutations accumulated by VRC01-class BCRs that become activated by the germline-targeting 426c.Mod.Core immunogen and the heterologous HxB2.WT.Core booster immunogen. We report that although the adjuvant used had no influence on the durability of plasma antibody responses after the prime, it influenced the plasma VRC01 antibody titers after the boost and the accumulation of somatic mutations on the elicited VRC01 antibodies.
Identifiants
pubmed: 36405776
doi: 10.1016/j.isci.2022.105473
pii: S2589-0042(22)01745-X
pmc: PMC9667313
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105473Subventions
Organisme : NIAID NIH HHS
ID : R01 AI104384
Pays : United States
Informations de copyright
© 2022 The Author(s).
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