Promoting oral mucosal wound healing using a DCS-RuB
BMSCs
DCS
Hydrogel
Light-responsive
Oral mucosa
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
31
08
2022
revised:
18
10
2022
accepted:
25
10
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
22
11
2022
Statut:
epublish
Résumé
The high occurrence rate and difficulties in symptom control are listed as the major problems of oral mucosal disease by medical professionals. Following the development of oral mucosal lesions, the oral microenvironment changes, immunity declines, and continuous bacterial stimulation causes wound infection. Traditional antibacterial drugs are ineffective for oral mucosal lesions. To overcome this problem, a light-responsive antibacterial hydrogel containing sustained-release BMSCs was inspired by the trauma environment in the oral cavity, which is different from that on the body surface since it mostly remains under dark conditions. In the absence of light, the hydrogel seals the wound to form a barrier, exerts a natural bacteriostatic effect, and prevents invasion by foreign bacteria. Simultaneously, mesenchymal stem cells are presented, and the released growth factors and other substances have excellent anti-inflammatory and angiogenic effects, which result in rapid repair of the damaged site. Under light conditions, after photo-induced shedding of the hydrogel, RuB
Identifiants
pubmed: 36406253
doi: 10.1016/j.bioactmat.2022.10.027
pii: S2452-199X(22)00451-0
pmc: PMC9650008
doi:
Types de publication
Journal Article
Langues
eng
Pagination
53-68Informations de copyright
© 2022 The Authors.
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