Multiple-Streams Focusing-Based Cell Separation in High Viscoelasticity Flow.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
15 Nov 2022
15 Nov 2022
Historique:
received:
17
09
2022
accepted:
25
10
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
22
11
2022
Statut:
epublish
Résumé
Viscoelastic flow has been widely used in microfluidic particle separation processes, in which particles get focused on the channel center in diluted viscoelastic flow. In this paper, the transition from single-stream focusing to multiple-streams focusing (MSF) in high viscoelastic flow is observed, which is applied for cell separation processes. Particle focusing stream bifurcation is caused by the balance between elastic force and viscoelastic secondary flow drag force. The influence of cell physical properties, such as cell dimension, shape, and deformability, on the formation of multiple-streams focusing is studied in detail. Particle separation is realized utilizing different separation criteria. The size-based separation of red (RBC) and white (WBC) blood cells is demonstrated in which cells get focused in different streams based on their dimension difference. Cells with different deformabilities get stretched in the viscoelastic flow, leading to the change of focusing streams, and this property is harnessed to separate red blood cells infected with the malaria parasite,
Identifiants
pubmed: 36406492
doi: 10.1021/acsomega.2c06021
pmc: PMC9670260
doi:
Types de publication
Journal Article
Langues
eng
Pagination
41759-41767Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133764
Pays : United States
Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Lab Chip. 2012 Apr 7;12(7):1347-54
pubmed: 22334376
Soft Matter. 2018 May 30;14(21):4238-4251
pubmed: 29561062
Nat Commun. 2019 Jan 24;10(1):415
pubmed: 30679420
Appl Phys Lett. 2019 Dec 23;115(26):263702
pubmed: 32127720
Anal Chem. 2021 Jan 26;93(3):1586-1595
pubmed: 33289547
Biophys J. 2019 Jul 9;117(1):14-24
pubmed: 31235179
Lab Chip. 2017 Sep 12;17(18):3078-3085
pubmed: 28805872
Anal Chem. 2012 Dec 4;84(23):10471-7
pubmed: 23163397
Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18892-7
pubmed: 18025477
Sci Rep. 2020 Dec 7;10(1):21385
pubmed: 33288839
Phys Rev Lett. 2007 Jun 8;98(23):234501
pubmed: 17677908
Micromachines (Basel). 2021 Mar 03;12(3):
pubmed: 33802356
J Oral Maxillofac Pathol. 2012 Sep;16(3):400-5
pubmed: 23248474
Nat Commun. 2013;4:2567
pubmed: 24108276
Lab Chip. 2018 Feb 13;18(4):551-567
pubmed: 29340388
Lab Chip. 2009 Nov 7;9(21):3038-46
pubmed: 19823716
Eur Phys J E Soft Matter. 2014 May;37(5):36
pubmed: 24839130
Anal Chem. 2021 Sep 21;93(37):12648-12654
pubmed: 34365786
Annu Rev Biomed Eng. 2014 Jul 11;16:371-96
pubmed: 24905880
Biomed Microdevices. 2015 Dec;17(6):110
pubmed: 26553099
Micromachines (Basel). 2019 Sep 10;10(9):
pubmed: 31510006
Anal Chem. 2015 Jun 16;87(12):6041-8
pubmed: 25989347
Lab Chip. 2012 May 7;12(9):1638-45
pubmed: 22426743
Analyst. 2019 Apr 8;144(8):2574-2583
pubmed: 30821313
Microsyst Nanoeng. 2020 Dec 14;6:113
pubmed: 34567720
Lab Chip. 2007 Dec;7(12):1644-59
pubmed: 18030382
Micromachines (Basel). 2022 Feb 25;13(3):
pubmed: 35334653
Asian J Androl. 2004 Dec;6(4):299-304
pubmed: 15546020
Science. 1978 Nov 24;202(4370):894-6
pubmed: 715448
Lab Chip. 2013 Mar 21;13(6):1121-32
pubmed: 23353899
Anal Chem. 2018 Apr 3;90(7):4397-4405
pubmed: 29537252
Analyst. 2021 May 21;146(10):3368-3377
pubmed: 33871507
Anal Chem. 2016 Dec 20;88(24):12303-12309
pubmed: 28193020
J Infect Dis. 2004 Jan 15;189(2):190-4
pubmed: 14722882
Biomicrofluidics. 2015 Jul 29;9(4):044108
pubmed: 26339309
Lab Chip. 2011 Jan 21;11(2):266-73
pubmed: 20976348
Anesth Analg. 2013 May;116(5):975-981
pubmed: 23449853
Biophys J. 2005 Aug;89(2):1055-66
pubmed: 15894648
Cell Microbiol. 2009 Sep;11(9):1340-53
pubmed: 19438513
Anal Chem. 2015 Nov 17;87(22):11523-30
pubmed: 26505113
Lab Chip. 2016 Jul 5;16(14):2626-35
pubmed: 27300118
Biomicrofluidics. 2016 Mar 21;10(2):024111
pubmed: 27051468
Sci Transl Med. 2013 Apr 3;5(179):179ra47
pubmed: 23552373
Biomed Eng Online. 2015 Jun 30;14:63
pubmed: 26123131