The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
11 Nov 2022
11 Nov 2022
Historique:
received:
23
05
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
22
11
2022
Statut:
epublish
Résumé
The multifactorial nature of Alzheimer's disease necessitates the development of agents able to interfere with different relevant targets. A series of 22 tailored chromanones was conceptualized, synthesized, and subjected to biological evaluation. We identified one representative bearing a linker-connected azepane moiety (compound
Identifiants
pubmed: 36407962
doi: 10.1021/acsptsci.2c00097
pmc: PMC9667544
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1097-1108Informations de copyright
© 2022 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): M.A.M.G. and C.D.B. are former employees of Eli Lilly & Company.
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