Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson's and Huntington's disease.
Huntington’s disease
Parkinson’s disease
amyotrophic lateral sclerosis
apathy
neuropsychology
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
30
08
2022
accepted:
14
10
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
22
11
2022
Statut:
epublish
Résumé
The semiology and determinants of apathy are largely unknown across amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Huntington's disease (HD), due to both motor and non-motor confounders. This study thus aimed at (1) profiling apathy in ALS, PD, and HD and (2) exploring its clinical determinants. Consecutive ALS ( Parkinson's disease and HD, but not ALS, patients were more apathetic than HCs-with HD patients also selectively showing lower initiation and poorer goal-directed planning than HCs. Higher apathetic features were detected in PD and HD as compared to ALS. Education was a protective factor against apathy in ALS. Anxiety was a risk factor for global apathy in ALS, HD, and to a lesser extent, in PD, whereas, protective only toward affective disintegration in PD and ALS. Cognitive inefficiency was a risk factor toward apathy in both PD and ALS. Depression was a risk factor for executive-related apathy in PD. This study provides unprecedented insights into the heterogeneous semiology and determinants of apathy across ALS, PD, and HD
Sections du résumé
Background
UNASSIGNED
The semiology and determinants of apathy are largely unknown across amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Huntington's disease (HD), due to both motor and non-motor confounders. This study thus aimed at (1) profiling apathy in ALS, PD, and HD and (2) exploring its clinical determinants.
Materials
UNASSIGNED
Consecutive ALS (
Results
UNASSIGNED
Parkinson's disease and HD, but not ALS, patients were more apathetic than HCs-with HD patients also selectively showing lower initiation and poorer goal-directed planning than HCs. Higher apathetic features were detected in PD and HD as compared to ALS. Education was a protective factor against apathy in ALS. Anxiety was a risk factor for global apathy in ALS, HD, and to a lesser extent, in PD, whereas, protective only toward affective disintegration in PD and ALS. Cognitive inefficiency was a risk factor toward apathy in both PD and ALS. Depression was a risk factor for executive-related apathy in PD.
Discussion
UNASSIGNED
This study provides unprecedented insights into the heterogeneous semiology and determinants of apathy across ALS, PD, and HD
Identifiants
pubmed: 36408105
doi: 10.3389/fnagi.2022.1031908
pmc: PMC9667083
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1031908Informations de copyright
Copyright © 2022 Poletti, Solca, Maffi, Torre, Carelli, Aiello, Ferrucci, Priori, Monti, Verde, Ticozzi, Migliore, Scaricamazza, Casella, Squitieri, Ciammola and Silani.
Déclaration de conflit d'intérêts
Author VS received compensation for consulting services and/or speaking activities from AveXis, Cytokinetics, Italfarmaco, Liquidweb S.r.l., and Novartis Pharma AG, received research supports from the Italian Ministry of Health, AriSLA, and E-Rare Joint Transnational Call, and was in the Editorial Board of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, European Neurology, American Journal of Neurodegenerative Diseases, Frontiers in Neurology. Authors BP and LC received compensation for consulting services and/or speaking activities from Liquidweb S.r.l. Author NT received compensation for consulting services from Amylyx Pharmaceuticals and Zambon Biotech SA. Author FSq received compensation for consulting services and/or speaking activities from La Hoffman-Roche, Novartis, PTC Therapeutics, Wave Life Science, Prilenia. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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