Development of neonatal brain functional centrality and alterations associated with preterm birth.
brain development
functional centrality
neonatal
preterm birth
resting-state connectivity
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
25 04 2023
25 04 2023
Historique:
received:
02
06
2022
revised:
21
09
2022
accepted:
11
10
2022
medline:
3
5
2023
pubmed:
22
11
2022
entrez:
21
11
2022
Statut:
ppublish
Résumé
Formation of the functional connectome in early life underpins future learning and behavior. However, our understanding of how the functional organization of brain regions into interconnected hubs (centrality) matures in the early postnatal period is limited, especially in response to factors associated with adverse neurodevelopmental outcomes such as preterm birth. We characterized voxel-wise functional centrality (weighted degree) in 366 neonates from the Developing Human Connectome Project. We tested the hypothesis that functional centrality matures with age at scan in term-born babies and is disrupted by preterm birth. Finally, we asked whether neonatal functional centrality predicts general neurodevelopmental outcomes at 18 months. We report an age-related increase in functional centrality predominantly within visual regions and a decrease within the motor and auditory regions in term-born infants. Preterm-born infants scanned at term equivalent age had higher functional centrality predominantly within visual regions and lower measures in motor regions. Functional centrality was not related to outcome at 18 months old. Thus, preterm birth appears to affect functional centrality in regions undergoing substantial development during the perinatal period. Our work raises the question of whether these alterations are adaptive or disruptive and whether they predict neurodevelopmental characteristics that are more subtle or emerge later in life.
Identifiants
pubmed: 36408638
pii: 6834174
doi: 10.1093/cercor/bhac444
pmc: PMC10152096
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5585-5596Subventions
Organisme : Wellcome Trust
ID : 206675/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006355/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P008712/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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