Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
14
11
2021
accepted:
03
10
2022
pubmed:
22
11
2022
medline:
3
1
2023
entrez:
21
11
2022
Statut:
ppublish
Résumé
Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 organ donors aged 11-93 years, we found a specific age-related decline in lung-associated, but not gut-associated, LN immune function linked to the accumulation of inhaled atmospheric particulate matter. Increasing densities of particulates were found in lung-associated LNs with age, but not in the corresponding gut-associated LNs. Particulates were specifically contained within CD68
Identifiants
pubmed: 36411343
doi: 10.1038/s41591-022-02073-x
pii: 10.1038/s41591-022-02073-x
pmc: PMC9835154
mid: NIHMS1860785
doi:
Substances chimiques
Dust
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2622-2632Subventions
Organisme : NIAID NIH HHS
ID : P01 AI106697
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL145547
Pays : United States
Organisme : NIH HHS
ID : S10 OD030282
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027050
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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