Orexin/Hypocretin System Dysfunction in ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations).
attention-deficit/hyperactivity disorder
autism spectrum disorder
developmental coordination disorder
hypocretin
neurodevelopmental disorders
orexin
research domain criteria
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
01
2022
accepted:
28
07
2022
entrez:
22
11
2022
pubmed:
23
11
2022
medline:
23
11
2022
Statut:
epublish
Résumé
Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE) is an umbrella term covering a wide range of neurodevelopmental difficulties and disorders. Thus, ESSENCE includes attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and other neurodevelopmental disorders (NDDs) and difficulties, with a variety of symptoms in cognitive, motor, sensory, social, arousal, regulatory, emotional, and behavioral developmental domains, frequently co-occurring and likely having partly common neurobiological substrates. The ESSENCE concept is a clinical paradigm that promotes organizing NDDs in everyday clinical practice according to their coexistence, symptom dimensions overlapping, and treatment possibilities. Despite increased knowledge regarding NDDs, the neurobiological mechanisms that underlie them and other ESSENCE-related problems, are not well understood. With its wide range of neural circuits and interactions with numerous neurotransmitters, the orexin/hypocretin system (Orx-S) is possibly associated with a variety of neurocognitive, psychobiological, neuroendocrine, and physiological functions and behaviors. Dysfunction of Orx-S has been implicated in various psychiatric and neurological disorders. This article provides an overview of Orx-S dysfunctions' possible involvement in the development, presentation, and maintenance of ESSENCE. We provide a focused review of current research evidence linking orexin neuropeptides with specific clinical NDDs symptoms, mostly in ADHD and ASD, within the Research Domain Criteria (RDoC) framework. We propose that Orx-S dysfunction might have an important role in some of these neurodevelopmental symptom domains, such as arousal, wakefulness, sleep, motor and sensory processing, mood and emotional regulation, fear processing, reward, feeding, attention, executive functions, and sociability. Our perspective is presented from a clinical point of view. Further, more thorough systematic reviews are needed as well as planning of extensive new research into the Orx-S's role in ESSENCE, especially considering RDoC elements.
Identifiants
pubmed: 36411777
doi: 10.2147/NDT.S358373
pii: 358373
pmc: PMC9675327
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2683-2702Informations de copyright
© 2022 Knez et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Am Fam Physician. 2021 Apr 15;103(8):481-492
pubmed: 33856167
Curr Med Chem. 2015 Feb 09;22(15):1850 - 59
pubmed: 25666800
Nat Commun. 2017 Nov 20;8(1):1606
pubmed: 29151577
Behav Brain Res. 2011 Aug 1;221(1):324-8
pubmed: 21420437
Psychoneuroendocrinology. 2019 Jul;105:178-186
pubmed: 30583940
Neuropharmacology. 2020 May 1;167:107993
pubmed: 32135427
Annu Rev Pharmacol Toxicol. 2011;51:243-66
pubmed: 21034217
Biomed Pharmacother. 2017 Jun;90:187-193
pubmed: 28360013
Molecules. 2021 Aug 11;26(16):
pubmed: 34443437
Nature. 2021 Jul;595(7866):283-288
pubmed: 34010947
Int Rev Res Dev Disabil. 2018;55:83-143
pubmed: 31799108
Autism Res. 2017 Jun;10(6):1022-1044
pubmed: 28401679
Neurobiol Dis. 2020 Feb;134:104615
pubmed: 31605778
Br J Pharmacol. 2014 Jan;171(2):294-313
pubmed: 23848055
Int J Play. 2020;9(1):108-127
pubmed: 33042634
Sleep. 2019 Feb 1;42(2):
pubmed: 30476304
Neurosci Biobehav Rev. 2021 Jan;120:479-508
pubmed: 33172600
Mil Med. 2020 Mar 2;185(3-4):363-369
pubmed: 31642481
Res Dev Disabil. 2017 Jan;60:232-242
pubmed: 27802895
Front Neurosci. 2018 Dec 18;12:934
pubmed: 30618563
Neuropsychiatr Dis Treat. 2018 Sep 17;14:2379-2387
pubmed: 30271154
J Intern Med. 2022 May;291(5):533-556
pubmed: 35043499
Nat Sci Sleep. 2021 Jul 23;13:1209-1224
pubmed: 34326674
Am J Psychiatry. 2010 Jul;167(7):748-51
pubmed: 20595427
JAMA Pediatr. 2021 Mar 1;175(3):e205487
pubmed: 33464287
Neurosci Lett. 2020 Jan 1;714:134592
pubmed: 31678432
Pharmacol Biochem Behav. 2019 Jul;182:22-34
pubmed: 31103523
Biol Psychiatry. 2005 Feb 15;57(4):319-27
pubmed: 15705346
Neuropsychopharmacology. 2018 Apr;43(5):1001-1009
pubmed: 28741623
Neurobiol Learn Mem. 2017 Dec;146:21-30
pubmed: 29107703
Neurosci Biobehav Rev. 2020 Nov;118:384-396
pubmed: 32768489
Obes Facts. 2022;15(3):305-320
pubmed: 35263756
Genes Brain Behav. 2021 Mar;20(3):e12707
pubmed: 33070452
Acta Paediatr. 2021 Oct;110(10):2825-2832
pubmed: 33876865
Neurotox Res. 2020 Jun;38(1):18-26
pubmed: 32207079
Alcohol Clin Exp Res. 2019 Aug;43(8):1702-1713
pubmed: 31206717
J Child Psychol Psychiatry. 2020 Dec;61(12):1309-1316
pubmed: 32020616
Neurosci Lett. 2020 Aug 24;734:135097
pubmed: 32485288
Acta Endocrinol (Buchar). 2019 Jan-Mar;-5(1):16-24
pubmed: 31149055
J Neuroinflammation. 2014 Mar 21;11:51
pubmed: 24655719
J Clin Med. 2021 Oct 19;10(20):
pubmed: 34682909
Front Neurol Neurosci. 2021;45:38-51
pubmed: 34052810
Cancers (Basel). 2021 May 26;13(11):
pubmed: 34073579
Nutrients. 2021 Jan 16;13(1):
pubmed: 33467150
Alzheimers Dement. 2022 Jun;18(6):1155-1163
pubmed: 34498801
J Clin Psychol. 2012 Oct;68(10):1111-21
pubmed: 22777931
Int J Eat Disord. 2016 Dec;49(12):1045-1057
pubmed: 27859581
Brain Sci. 2020 Mar 13;10(3):
pubmed: 32182969
Neuropsychiatr Dis Treat. 2019 Aug 06;15:2221-2230
pubmed: 31496705
Scand J Psychol. 2018 Aug;59(4):428-432
pubmed: 29738079
Eur Child Adolesc Psychiatry. 2012 Mar;21(3):141-7
pubmed: 22323074
J Endocrinol Invest. 2014 Mar;37(3):285-92
pubmed: 24515297
Sleep Med. 2020 Jan;65:84-88
pubmed: 31739230
Vision (Basel). 2019 May 24;3(2):
pubmed: 31735823
Transl Psychiatry. 2020 Aug 17;10(1):284
pubmed: 32801330
Peptides. 2009 Dec;30(12):2348-56
pubmed: 19666069
Nat Neurosci. 2014 Oct;17(10):1298-303
pubmed: 25254979
Brain Sci. 2020 Jun 10;10(6):
pubmed: 32531995
Mol Psychiatry. 2011 Nov;16(11):1147-54
pubmed: 20856250
Nat Sci Sleep. 2021 Sep 28;13:1687-1688
pubmed: 34611454
Sleep Med Rev. 2021 Jun;57:101432
pubmed: 33567377
Neuroreport. 2015 Dec 2;26(17):1017-22
pubmed: 26445284
Med Hypotheses. 2008 Nov;71(5):770-5
pubmed: 18678446
Front Psychiatry. 2020 Apr 08;11:265
pubmed: 32322223
Atten Defic Hyperact Disord. 2015 Dec;7(4):249-69
pubmed: 25957598
Front Neurol. 2021 May 04;12:666980
pubmed: 34017307
Front Psychiatry. 2021 May 31;12:676336
pubmed: 34135789
Pediatr Int. 2018 Nov;60(11):1034-1035
pubmed: 30407706
Neuroscience. 2009 Dec 1;164(2):629-40
pubmed: 19703526
Pharmacotherapy. 2004 Sep;24(9):1177-85
pubmed: 15460178
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64
pubmed: 19246384
Atten Defic Hyperact Disord. 2018 Mar;10(1):21-47
pubmed: 28401487
Psychiatry Res Neuroimaging. 2017 Apr 30;262:55-62
pubmed: 28235692
Br J Pharmacol. 2014 Jan;171(2):314-31
pubmed: 23902572
Neuroscience. 2010 Apr 28;167(1):11-20
pubmed: 20149847
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:1-7
pubmed: 30576764
Open Life Sci. 2021 Jan 20;16(1):46-52
pubmed: 33817297
Curr Top Behav Neurosci. 2017;33:17-50
pubmed: 27909990
Front Neurol Neurosci. 2021;45:61-74
pubmed: 34052814
Brain Res. 2020 Mar 15;1731:145915
pubmed: 30125533
Front Psychiatry. 2019 Jul 17;10:473
pubmed: 31404299
Compr Psychiatry. 2019 Apr;90:65-72
pubmed: 30743139
Front Neurol Neurosci. 2021;45:11-21
pubmed: 34052806
J Clin Sleep Med. 2020 Mar 15;16(3):415-421
pubmed: 31992394
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20260-5
pubmed: 24277819
Sleep. 2016 Apr 01;39(4):855-60
pubmed: 26943469
Dev Psychobiol. 2009 Mar;51(2):207-11
pubmed: 18988196
Brain Sci. 2020 Jul 08;10(7):
pubmed: 32650534
Nutrients. 2018 Oct 01;10(10):
pubmed: 30275418
Front Neuroanat. 2017 Nov 27;11:110
pubmed: 29230167
Nat Rev Neurol. 2019 Sep;15(9):519-539
pubmed: 31324898
Endocrinology. 2001 Aug;142(8):3324-31
pubmed: 11459774
Brain. 2011 Dec;134(Pt 12):3477-89
pubmed: 21930661
Epidemiology. 2010 Nov;21(6):805-8
pubmed: 20798635
Brain. 2018 Sep 1;141(9):2795-2805
pubmed: 30016410
ScientificWorldJournal. 2013 Apr 15;2013:315429
pubmed: 23690743
Neuropsychiatr Dis Treat. 2021 Feb 10;17:379-388
pubmed: 33603376
Pediatr Res. 2014 Jan;75(1-2):210-6
pubmed: 24192703
Early Hum Dev. 2001 Oct;65(1):21-37
pubmed: 11520626
Neuron. 2005 Jun 2;46(5):787-98
pubmed: 15924864
J Pharmacol Exp Ther. 2005 Sep;314(3):1322-7
pubmed: 15947034
Neurol Sci. 2019 Mar;40(3):593-602
pubmed: 30617449
Eur J Hum Genet. 2019 Sep;27(9):1445-1455
pubmed: 30976114
PLoS Genet. 2019 Dec 5;15(12):e1008488
pubmed: 31805042
S Afr J Psychiatr. 2019 Jan 22;25:1232
pubmed: 30899581
J Intellect Disabil Res. 2010 May;54(5):448-56
pubmed: 20537050
J Intellect Disabil Res. 2010 Apr;54(4):346-53
pubmed: 20433572
Trends Mol Med. 2021 Sep;27(9):895-906
pubmed: 34175230
BMC Med Genomics. 2020 Oct 28;13(1):160
pubmed: 33115496
Dialogues Clin Neurosci. 2020 Mar;22(1):65-72
pubmed: 32699506
Cell. 2011 Jul 22;146(2):194-207
pubmed: 21784243
Neuropsychopharmacology. 2020 Jan;45(1):129-140
pubmed: 31302665
Arch Dis Child. 2003 Oct;88(10):904-10
pubmed: 14500312
Neurosci Biobehav Rev. 2015 Feb;49:43-54
pubmed: 25511388
eNeuro. 2022 Apr 13;9(2):
pubmed: 35365504
Lancet. 2016 Mar 19;387(10024):1240-50
pubmed: 26386541
J Neurosci. 2007 Mar 14;27(11):2837-45
pubmed: 17360905
Res Dev Disabil. 2010 Nov-Dec;31(6):1543-51
pubmed: 20634041
J Autism Dev Disord. 2009 Feb;39(2):231-41
pubmed: 18629623
Front Aging Neurosci. 2022 Jan 25;13:826213
pubmed: 35145394
Transl Psychiatry. 2020 Aug 7;10(1):273
pubmed: 32769967
Lakartidningen. 2014 Sep 23;111(39):1643-6
pubmed: 25253610
Brain Res. 2020 Mar 15;1731:146085
pubmed: 30590027
Brain Res. 2021 Jan 15;1751:147199
pubmed: 33160959
PLoS One. 2017 Aug 1;12(8):e0182085
pubmed: 28763482
Neurosci Biobehav Rev. 2017 Mar;74(Pt B):376-392
pubmed: 27477446
J Physiol. 2016 Nov 15;594(22):6443-6462
pubmed: 27302606
Front Neurol Neurosci. 2021;45:128-138
pubmed: 34052807
Sci Rep. 2017 Aug 15;7(1):8228
pubmed: 28811624
Front Psychol. 2016 May 06;7:666
pubmed: 27199879
Front Physiol. 2017 May 31;8:357
pubmed: 28620314
Front Neurol Neurosci. 2021;45:52-60
pubmed: 34052808
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4525-4530
pubmed: 28396414
Front Neurosci. 2014 Feb 12;8:22
pubmed: 24574958
Acta Paediatr. 2008 Jun;97(6):819-21
pubmed: 18430075
Front Psychiatry. 2021 Jun 09;12:668297
pubmed: 34177659
Front Neurosci. 2014 Feb 13;8:26
pubmed: 24592206
Neurosci Biobehav Rev. 2021 May;124:179-192
pubmed: 33549742
Neurosci Bull. 2013 Jun;29(3):355-65
pubmed: 23299718
Neuropsychiatr Dis Treat. 2016 Aug 25;12:2149-64
pubmed: 27601909
Brain Circ. 2020 Jun 26;6(2):70-80
pubmed: 33033776
Brain Res. 2003 Jan 17;960(1-2):48-61
pubmed: 12505657
Biol Psychol. 2017 Mar;124:11-20
pubmed: 28099875
Front Immunol. 2022 Feb 09;13:829058
pubmed: 35222413
Front Physiol. 2018 Mar 22;9:261
pubmed: 29623047
Neurodegener Dis. 2014;14(2):98-106
pubmed: 24992945
Autism Res. 2020 Feb;13(2):182-186
pubmed: 31593375
J Psychiatr Res. 2021 Apr;136:529-536
pubmed: 33127071
Ann Neurosci. 2016 Jul;23(2):81-8
pubmed: 27647958
Dev Psychopathol. 2021 Aug;33(3):767-777
pubmed: 32102703
Neurochem Int. 2020 Dec;141:104882
pubmed: 33068686
J Clin Psychiatry. 2003 Oct;64(10):1145-6
pubmed: 14658960
Psychoneuroendocrinology. 2014 Nov;49:207-28
pubmed: 25108163
J Child Adolesc Psychopharmacol. 2017 Nov;27(9):792-795
pubmed: 28520464
Diabetes Metab Res Rev. 2020 Mar;36(3):e3229
pubmed: 31655012
Mol Autism. 2018 Jan 30;9:9
pubmed: 29423135
Front Neurosci. 2015 Jul 03;9:225
pubmed: 26190965
JAMA Psychiatry. 2018 Aug 1;75(8):797-808
pubmed: 29898209
Sleep. 2015 Aug 01;38(8):1285-95
pubmed: 26118560
Curr Top Behav Neurosci. 2022;58:237-254
pubmed: 35397066
Front Neurol. 2018 Jun 06;9:413
pubmed: 29928253
Med Res Rev. 2015 Jan;35(1):152-97
pubmed: 25044006
Cureus. 2020 Jun 4;12(6):e8436
pubmed: 32642351
Psychol Rev. 2004 Oct;111(4):984-1002
pubmed: 15482070
Arch Neurol. 2012 Feb;69(2):230-8
pubmed: 22332190
Neuropsychol Rev. 2017 Mar;27(1):46-61
pubmed: 28102493
J Clin Sleep Med. 2008 Jun 15;4(3):248-54
pubmed: 18595438
Med Hypotheses. 2016 Dec;97:131-133
pubmed: 27876121
Front Immunol. 2014 Mar 31;5:136
pubmed: 24744759
Expert Opin Pharmacother. 2019 Dec;20(18):2257-2271
pubmed: 31638842
Front Psychiatry. 2021 Nov 16;12:767075
pubmed: 34867553
J Neurosci. 2013 Sep 4;33(36):14549-57
pubmed: 24005305
Am J Hum Genet. 2015 Jan 8;96(1):136-46
pubmed: 25574827
Neuropsychiatr Dis Treat. 2018 Jul 24;14:1883-1889
pubmed: 30100723
Lakartidningen. 2019 Sep 17;116:
pubmed: 31529419
Curr Psychiatry Rep. 2020 Jun 5;22(8):36
pubmed: 32514698