Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape.
DNA methylation
astrocytes
cancer biology
glioblastoma
human
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
22 11 2022
22 11 2022
Historique:
received:
25
01
2022
accepted:
01
11
2022
entrez:
22
11
2022
pubmed:
23
11
2022
medline:
24
11
2022
Statut:
epublish
Résumé
We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identification of enriched predicted binding sites of transcription factors known to cause demethylation and to be involved in astrocytic/glial lineage specification, point to a shared ontogeny between these glioblastomas and astroglial progenitors. At functional level, increased invasiveness, at least in part mediated by SRPX2, and macrophage infiltration characterise this subset of glioblastoma.
Identifiants
pubmed: 36412091
doi: 10.7554/eLife.77335
pii: 77335
pmc: PMC9681209
doi:
pii:
Banques de données
GEO
['GSE196418', 'GSE196339', 'GSE154958', 'GSE155985', 'GSE163120', 'GSE152160']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cancer Research UK
ID : C23985/A29199
Pays : United Kingdom
Informations de copyright
© 2022, Boot et al.
Déclaration de conflit d'intérêts
JB, GR, DK, CV, YL, NP, XZ, LG, DS, MB, SB, SN, KM, SM No competing interests declared
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