Aetiology of long bone chronic osteomyelitis: an analysis of the current situation in one region in Egypt.
Gram-negative bacilli
Methicillin-resistant
Multidrug-resistant
Osteomyelitis
Polymicrobial
Staphylococcus aureus
Journal
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
ISSN: 1432-1068
Titre abrégé: Eur J Orthop Surg Traumatol
Pays: France
ID NLM: 9518037
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
23
08
2022
accepted:
09
11
2022
pubmed:
23
11
2022
medline:
28
3
2023
entrez:
22
11
2022
Statut:
ppublish
Résumé
Chronic osteomyelitis (COM) is a devastating infection requiring a multidisciplinary approach, including radiology, microbiology, pathology, and orthopaedic surgery to treat. The present study analysed the bacterial profile causing chronic osteomyelitis and their antibiogram in our region. PATIENTS AND METHODS: This prospective study was done on a consecutive group of patients who underwent surgical debridement for long bone COM. Three to six deep tissue samples were collected during the index debridement for microbiology and one sample for histopathology. Antimicrobial sensitivity testing used an automated bacterial identification system. Gram stain was used to identify the bacteria type from its size, shape, and arrangement of bacterial growth. Intra-operative deep tissue and bone specimens accurately identified causative bacteria in 84.8% of patients. Gram-ve bacilli (GNB) were the most common causative organisms in 51.6% of all growing samples (36.4% isolated G-ve and 15.2% mixed with G + ve). Thirty-three patients (30 males/three females) were included; the mean age at index debridement surgery was 37.1 years. Half of the cohort had no metalwork. The aetiology of COM was post-operative infection in half of the patients. There may be concerning features in our patients' aetiologies and causative organisms; closed fractures turn into COM postoperatively, several unsuccessful attempts, delayed index debridement, and more GNB. Plans need to be applied to break the cycle and improve outcomes.
Identifiants
pubmed: 36414874
doi: 10.1007/s00590-022-03429-2
pii: 10.1007/s00590-022-03429-2
pmc: PMC10036446
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
507-513Informations de copyright
© 2022. The Author(s).
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