Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study.
Antidepressants
Autism spectrum disorder
Neurodevelopment
Prenatal
Journal
Research on child and adolescent psychopathology
ISSN: 2730-7174
Titre abrégé: Res Child Adolesc Psychopathol
Pays: United States
ID NLM: 101773609
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
accepted:
14
11
2022
pmc-release:
01
04
2024
pubmed:
24
11
2022
medline:
21
3
2023
entrez:
23
11
2022
Statut:
ppublish
Résumé
Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO) program (N = 3129) to test for this association, and determine whether the association remained after adjusting for maternal prenatal depression and other potential confounders. Antidepressants and a subset of selective serotonin reuptake inhibitors (SSRIs) were examined in relation to binary (e.g., diagnostic) and continuous measures of ASD and ASD related traits (e.g., social difficulties, behavior problems) in children 1.5 to 12 years of age. Child sex was tested as an effect modifier. While prenatal antidepressant exposure was associated with ASD related traits in univariate analyses, these associations were statistically non-significant in models that adjusted for prenatal maternal depression and other maternal and child characteristics. Sex assigned at birth was not an effect modifier for the prenatal antidepressant and child ASD relationship. Overall, we found no association between prenatal antidepressant exposures and ASD diagnoses or traits. Discontinuation of antidepressants in pregnancy does not appear to be warranted on the basis of increased risk for offspring ASD.
Identifiants
pubmed: 36417100
doi: 10.1007/s10802-022-01000-5
pii: 10.1007/s10802-022-01000-5
pmc: PMC10150657
mid: NIHMS1889538
doi:
Substances chimiques
Antidepressive Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
513-527Subventions
Organisme : NIH HHS
ID : UH3 OD023249
Pays : United States
Organisme : NIH HHS
ID : U2C OD023375
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023285
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023320
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023318
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023271
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023282
Pays : United States
Organisme : NIH HHS
ID : U24 OD023319
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023305
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023272
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023347
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023279
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023342
Pays : United States
Organisme : NIH HHS
ID : U24 OD023382
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023313
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES029490
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023244
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023320
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023349
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023365
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023337
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023318
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023249
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023328
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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