Enhancement of Immunosuppressive Activity of Mesenchymal Stromal Cells by Platelet-Derived Factors is Accompanied by Apoptotic Priming.
Apoptosis
Autophagy
Extracellular vesicles
Fibrin
Hematoma
Immunomodulation
Mesenchymal stromal cells
Metabolism
Platelet-rich plasma
Senescence
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
accepted:
19
10
2022
medline:
5
4
2023
pubmed:
24
11
2022
entrez:
23
11
2022
Statut:
ppublish
Résumé
The pro-inflammatory phase of bone healing, initiated by platelet activation and eventually hematoma formation, impacts bone marrow mesenchymal stromal cells (MSCs) in unknown ways. Here, we created platelet-rich plasma (PRP) hydrogels to study how platelet-derived factors modulate functional properties of encapsulated MSCs in comparison to a non-inflammatory fibrin (FBR) hydrogel environment. MSCs were isolated from human bone marrow, while PRP was collected from pooled apheresis thrombocyte concentrates and used for hydrogel preparation. After their encapsulation in hydrogels for 72 h, retrieved MSCs were analyzed for immunomodulatory activities, apoptosis, stem cell properties, senescence, CD9
Identifiants
pubmed: 36417151
doi: 10.1007/s12015-022-10471-4
pii: 10.1007/s12015-022-10471-4
pmc: PMC10070232
doi:
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
713-733Informations de copyright
© 2022. The Author(s).
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