Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish.
CP: Developmental biology
CP: Neuroscience
adult neurogenesis
eural stem cells
myostatin
neuronal differentiation
regeneration
spinal cord injury
zebrafish
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
22 11 2022
22 11 2022
Historique:
received:
08
09
2021
revised:
16
05
2022
accepted:
01
11
2022
entrez:
23
11
2022
pubmed:
24
11
2022
medline:
26
11
2022
Statut:
ppublish
Résumé
Intrinsic and extrinsic inhibition of neuronal regeneration obstruct spinal cord (SC) repair in mammals. In contrast, adult zebrafish achieve functional recovery after complete SC transection. While studies of innate SC regeneration have focused on axon regrowth as a primary repair mechanism, how local adult neurogenesis affects functional recovery is unknown. Here, we uncover dynamic expression of zebrafish myostatin b (mstnb) in a niche of dorsal SC progenitors after injury. mstnb mutants show impaired functional recovery, normal glial and axonal bridging across the lesion, and an increase in the profiles of newborn neurons. Molecularly, neuron differentiation genes are upregulated, while the neural stem cell maintenance gene fgf1b is downregulated in mstnb mutants. Finally, we show that human fibroblast growth factor 1 (FGF1) treatment rescues the molecular and cellular phenotypes of mstnb mutants. These studies uncover unanticipated neurogenic functions for mstnb and establish the importance of local adult neurogenesis for innate SC repair.
Identifiants
pubmed: 36417881
pii: S2211-1247(22)01579-0
doi: 10.1016/j.celrep.2022.111705
pmc: PMC9742758
mid: NIHMS1852530
pii:
doi:
Substances chimiques
Myostatin
0
Fibroblast Growth Factor 1
104781-85-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111705Subventions
Organisme : NINDS NIH HHS
ID : R01 NS113915
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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