Waist-to-height ratio is a simple and practical alternative to waist circumference to diagnose metabolic syndrome in type 2 diabetes.

insulin resistance metabolic syndrome type 2 diabetes mellitus waist circumference waist-to-height ratio

Journal

Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264

Informations de publication

Date de publication:
2022
Historique:
received: 04 07 2022
accepted: 20 10 2022
entrez: 24 11 2022
pubmed: 25 11 2022
medline: 25 11 2022
Statut: epublish

Résumé

As an indicator of abdominal obesity, waist circumference (WC) varied with race and gender in diagnosing metabolic syndrome (MetS). Therefore, it is clinically important to find an alternative indicator of abdominal obesity independent of these factors to diagnose MetS. Our aims were to evaluate the association between waist-to-height ratio (WHtR) and MetS and further determine whether WHtR could be used as a simple and practical alternative to WC to diagnose MetS in patients with type 2 diabetes mellitus (T2DM). This cross-sectional, real-world study recruited 8488 hospitalized T2DM patients including 3719 women (43.8%) aged from 18 to 94 years and 4769 men (56.2%) aged from 18 to 91 years. A WHtR cut-off of 0.52 was used to diagnose MetS in both men and women T2DM patients based on our previous study. The association of WHtR with MetS in T2DM patients was analyzed by binary logistic regression. The consistency of two diagnostic criteria for MetS according to WC and WHtR was determined by Kappa test. The prevalence of MetS according to WHtR was 79.4% in women and 68.6% in men T2DM patients, which was very close to the prevalence of MetS according to WC in both women (82.6%) and men (68.3%). The prevalence of MetS diagnosed by WC in both men and women with WHtR ≥ 0.52 was significantly higher than in those with WHtR < 0.52 after adjustment for age and duration of diabetes (89.2 vs. 38.7% for men; 92.8 vs. 57.4% for women; respectively, all WHtR is independently associated with the presence of MetS and can be used as a simple and practical alternative to WC to diagnose MetS regardless of gender in T2DM patients.

Sections du résumé

Background UNASSIGNED
As an indicator of abdominal obesity, waist circumference (WC) varied with race and gender in diagnosing metabolic syndrome (MetS). Therefore, it is clinically important to find an alternative indicator of abdominal obesity independent of these factors to diagnose MetS. Our aims were to evaluate the association between waist-to-height ratio (WHtR) and MetS and further determine whether WHtR could be used as a simple and practical alternative to WC to diagnose MetS in patients with type 2 diabetes mellitus (T2DM).
Methods UNASSIGNED
This cross-sectional, real-world study recruited 8488 hospitalized T2DM patients including 3719 women (43.8%) aged from 18 to 94 years and 4769 men (56.2%) aged from 18 to 91 years. A WHtR cut-off of 0.52 was used to diagnose MetS in both men and women T2DM patients based on our previous study. The association of WHtR with MetS in T2DM patients was analyzed by binary logistic regression. The consistency of two diagnostic criteria for MetS according to WC and WHtR was determined by Kappa test.
Results UNASSIGNED
The prevalence of MetS according to WHtR was 79.4% in women and 68.6% in men T2DM patients, which was very close to the prevalence of MetS according to WC in both women (82.6%) and men (68.3%). The prevalence of MetS diagnosed by WC in both men and women with WHtR ≥ 0.52 was significantly higher than in those with WHtR < 0.52 after adjustment for age and duration of diabetes (89.2 vs. 38.7% for men; 92.8 vs. 57.4% for women; respectively, all
Conclusion UNASSIGNED
WHtR is independently associated with the presence of MetS and can be used as a simple and practical alternative to WC to diagnose MetS regardless of gender in T2DM patients.

Identifiants

DOI: 10.3389/fnut.2022.986090 PMID: 36419559 PMC: PMC9676651
pubmed: 36419559
doi: 10.3389/fnut.2022.986090
pmc: PMC9676651
doi:

Types de publication

Journal Article

Langues

eng

Pagination

986090

Informations de copyright

Copyright © 2022 Ma, Jin, Zhao, Ke, Wang, Wang, Lu, Huang and Li.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Endocrine. 2021 Apr;72(1):86-95
pubmed: 33400176
Diabet Med. 2008 Dec;25(12):1419-25
pubmed: 19046240
Diabetes Care. 2004 Sep;27(9):2135-40
pubmed: 15333474
Nutrients. 2021 Dec 15;13(12):
pubmed: 34960027
Compr Physiol. 2013 Jan;3(1):1-58
pubmed: 23720280
J Diabetes Complications. 2012 Jan-Feb;26(1):23-8
pubmed: 22226486
Lancet. 2005 Apr 16-22;365(9468):1415-28
pubmed: 15836891
Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1039-49
pubmed: 18356555
Int J Food Sci Nutr. 2005 Aug;56(5):303-7
pubmed: 16236591
Diabetologia. 1991 Jun;34(6):416-22
pubmed: 1884900
Circulation. 2002 Dec 17;106(25):3143-421
pubmed: 12485966
Diabetes Metab Syndr Obes. 2013 Oct 24;6:403-19
pubmed: 24179379
J Nutr Health Aging. 2010 Nov;14(9):782-5
pubmed: 21085910
Lancet. 2005 Apr 9-15;365(9467):1333-46
pubmed: 15823385
J Clin Epidemiol. 2008 Jul;61(7):646-53
pubmed: 18359190
Diabetes Care. 2011 Jan;34(1):e7
pubmed: 21193616
Diabetes Res Clin Pract. 2022 Jan;183:109151
pubmed: 34863718
Clin Dermatol. 2018 Jan - Feb;36(1):14-20
pubmed: 29241747
J Am Coll Cardiol. 2010 Sep 28;56(14):1113-32
pubmed: 20863953
Br J Nutr. 2014 Nov 28;112(10):1735-44
pubmed: 25300318
Lancet. 2005 Sep 24-30;366(9491):1059-62
pubmed: 16182882
Cardiovasc Diabetol. 2013 Jan 16;12:18
pubmed: 23324539
Pediatr Diabetes. 2019 Aug;20(5):530-537
pubmed: 30968521
J Hypertens. 2015 Mar;33(3):482-90; discussion 490
pubmed: 25405332
Diabetol Metab Syndr. 2022 Apr 12;14(1):50
pubmed: 35413936
Front Public Health. 2021 Oct 07;9:726288
pubmed: 34692623
Diabet Med. 2008 Dec;25(12):1412-8
pubmed: 19046239
Nutrients. 2019 Oct 29;11(11):
pubmed: 31671800
Diabetes Metab J. 2022 Jan;46(1):129-139
pubmed: 34372627
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
Transl Res. 2017 May;183:57-70
pubmed: 28130064
Sci Rep. 2021 Apr 15;11(1):8224
pubmed: 33859227
Diabetes. 1992 Jun;41(6):715-22
pubmed: 1587398
Medicine (Baltimore). 2019 Oct;98(42):e17620
pubmed: 31626142
Diabetes Metab Syndr Obes. 2021 Mar 30;14:1431-1443
pubmed: 33833536
Nutr Metab (Lond). 2021 Jan 6;18(1):3
pubmed: 33407674
Diabetes Care. 2003 Apr;26(4):1297-303
pubmed: 12663612
J Diabetes Investig. 2016 Jul;7(4):594-600
pubmed: 27181602
Front Endocrinol (Lausanne). 2021 Aug 04;12:706845
pubmed: 34421824
Obes Facts. 2020;13(6):538-547
pubmed: 33232966
Hypertens Res. 2013 Jan;36(1):36-42
pubmed: 22951523
Nutr J. 2018 Nov 22;17(1):109
pubmed: 30466421
Diabet Med. 1998 Jul;15(7):539-53
pubmed: 9686693
Adv Nutr. 2017 Sep 15;8(5):718-727
pubmed: 28916572
Res Sports Med. 2020 Jan-Mar;28(1):15-26
pubmed: 30044132
Obes Rev. 2012 Mar;13(3):275-86
pubmed: 22106927
Circulation. 2005 Oct 25;112(17):2735-52
pubmed: 16157765
Int J Environ Res Public Health. 2021 Dec 29;19(1):
pubmed: 35010598
Cardiol Res Pract. 2020 Mar 16;2020:4250793
pubmed: 32257425
Lancet Diabetes Endocrinol. 2014 Nov;2(11):901-10
pubmed: 24731669
BMC Public Health. 2020 Aug 31;20(1):1317
pubmed: 32867710
J Ren Nutr. 2019 Jul;29(4):302-309.e1
pubmed: 30581064
Lancet. 2005 Apr 16-22;365(9468):1398-405
pubmed: 15836888

Auteurs

Yi-Lin Ma (YL)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Chun-Hua Jin (CH)

Department of Endocrinology and Metabolism, Shanghai Songjiang District Central Hospital, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, China.

Cui-Chun Zhao (CC)

Department of VIP, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jiang-Feng Ke (JF)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Jun-Wei Wang (JW)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Yu-Jie Wang (YJ)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Jun-Xi Lu (JX)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Gao-Zhong Huang (GZ)

Department of VIP, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Lian-Xi Li (LX)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Classifications MeSH