PDAC-on-chip for

Humans Interleukin-6 Pancreatic Neoplasms / drug therapy Carcinoma, Pancreatic Ductal / pathology Pancreas / metabolism Tumor Microenvironment Cell Line, Tumor Pancreatic Neoplasms

Journal

Biomaterials science
ISSN: 2047-4849
Titre abrégé: Biomater Sci
Pays: England
ID NLM: 101593571

Informations de publication

Date de publication:
20 Dec 2022
Historique:
pubmed: 25 11 2022
medline: 23 12 2022
entrez: 24 11 2022
Statut: epublish

Résumé

Pancreatic ductal adenocarcinoma (PDAC) mainly develops in the head of the pancreas, within the acino-ductal unit composed of acinar and ductal cells surrounded by pancreatic stellate cells (PSCs). PSCs strongly influence the tumor microenvironment by triggering an intense stromal deposition, which plays a key role in tumor progression and limits drug perfusion. We have developed a microfluidic

Identifiants

DOI: 10.1039/d2bm00881e PMID: 36420859
pubmed: 36420859
doi: 10.1039/d2bm00881e
doi:

Substances chimiques

Interleukin-6 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

208-224

Auteurs

Viola Sgarminato (V)

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. chiara.tondaturo@polito.it.
Department of Surgical Sciences, Università degli Studi di Torino, Corso Dogliotti, 14, 10126 Torino, Italy.

Simone Luigi Marasso (SL)

Chilab - Materials and Microsystems Laboratory, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Chivasso, TO, Italy.
CNR-IMEM, Parco Area delle Scienze, Parma, Italy.
ORCID: 0000-0003-4570-2674

Matteo Cocuzza (M)

Chilab - Materials and Microsystems Laboratory, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Chivasso, TO, Italy.
CNR-IMEM, Parco Area delle Scienze, Parma, Italy.
POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy.

Giorgio Scordo (G)

Chilab - Materials and Microsystems Laboratory, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Chivasso, TO, Italy.

Alberto Ballesio (A)

Chilab - Materials and Microsystems Laboratory, Department of Applied Science and Technology (DISAT), Politecnico di Torino, Chivasso, TO, Italy.

Gianluca Ciardelli (G)

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. chiara.tondaturo@polito.it.
POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy.
Department for Materials and Devices of the National Research Council, Institute for the Chemical and Physical Processes (CNR-IPCF UOS), Pisa, Italy.

Chiara Tonda-Turo (C)

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. chiara.tondaturo@polito.it.
POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy.
ORCID: 0000-0002-2149-7533

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PDAC-on-chip for
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › PDAC-on-chip for
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › PDAC-on-chip for
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › PDAC-on-chip for
questionsmedicales.fr › Système digestif › Pancréas › PDAC-on-chip for
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › PDAC-on-chip for
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › PDAC-on-chip for
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › PDAC-on-chip for