Integrating Mechanisms in Thrombotic Peripheral Arterial Disease.
atherosclerosis
coagulation
peripheral artery disease
thrombosis
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
received:
11
10
2022
revised:
12
11
2022
accepted:
14
11
2022
entrez:
24
11
2022
pubmed:
25
11
2022
medline:
25
11
2022
Statut:
epublish
Résumé
Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the development of new treatments. This review aims to highlight the essential elements of atherosclerosis contributing to the pathophysiology of PAD. Furthermore, emphasis will be placed on the role of thrombo-inflammation, with particular focus on platelet and coagulation activation as well as cell-cell interactions. Additional insight will be then discussed to reveal the contribution of hypercoagulability to the development of vascular diseases such as PAD. Lastly, the current antithrombotic treatments will be discussed, and light will be shed on promising new targets aiming to aid the development of new treatments.
Identifiants
pubmed: 36422558
pii: ph15111428
doi: 10.3390/ph15111428
pmc: PMC9695058
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Innate Immun. 2009;1(3):225-30
pubmed: 20375580
Sci Transl Med. 2019 Nov 6;11(517):
pubmed: 31694925
Semin Vasc Surg. 2010 Dec;23(4):221-7
pubmed: 21194639
Blood. 2017 Dec 28;130(26):2819-2828
pubmed: 29018081
JAMA Netw Open. 2022 Jun 1;5(6):e2215580
pubmed: 35731517
J Am Heart Assoc. 2017 May 3;6(5):
pubmed: 28468784
Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2054-61
pubmed: 16037567
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12367-71
pubmed: 14519852
Int J Mol Sci. 2020 Sep 15;21(18):
pubmed: 32942605
Nat Med. 2010 Aug;16(8):887-96
pubmed: 20676107
Circulation. 2004 Aug 10;110(6):738-43
pubmed: 15262830
N Engl J Med. 2006 Apr 20;354(16):1706-17
pubmed: 16531616
Int J Mol Sci. 2021 May 29;22(11):
pubmed: 34072544
Blood. 2009 Jul 23;114(4):881-90
pubmed: 19372258
Nat Med. 2002 Mar;8(3):247-52
pubmed: 11875495
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1271-1282
pubmed: 29599135
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6388-93
pubmed: 17405864
Nat Commun. 2018 Nov 1;9(1):4567
pubmed: 30385745
Circulation. 2005 Jun 28;111(25):3481-8
pubmed: 15983262
Hepatology. 2015 Aug;62(2):600-14
pubmed: 25855125
J Thromb Haemost. 2005 Aug;3(8):1800-14
pubmed: 16102047
Free Radic Biol Med. 2021 May 20;168:95-109
pubmed: 33789125
Proc Natl Acad Sci U S A. 1989 Apr;86(8):2839-43
pubmed: 2704749
Crit Rev Biochem Mol Biol. 2015;50(4):326-36
pubmed: 26018600
Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1521-1533
pubmed: 33657880
Front Pharmacol. 2017 Sep 14;8:647
pubmed: 28959204
Semin Thromb Hemost. 2016 Apr;42(3):205-14
pubmed: 26886394
Eur Heart J. 2022 Feb 10;43(6):504-514
pubmed: 34529782
J Invasive Cardiol. 2001 Dec;13(12):767-71
pubmed: 11731685
Cardiovasc Res. 2018 Oct 1;114(12):1578-1594
pubmed: 29982301
J Thromb Haemost. 2014 Dec;12(12):2074-88
pubmed: 25163512
Cell. 2009 Dec 11;139(6):1143-56
pubmed: 20005807
Circulation. 2010 Aug 24;122(8):821-30
pubmed: 20697022
J Am Coll Cardiol. 2018 Jan 2;71(1):53-65
pubmed: 29301628
Eur Heart J. 2015 Nov 14;36(43):2984-7
pubmed: 26206212
Blood. 2015 May 7;125(19):2898-907
pubmed: 25824691
J Exp Med. 2012 Apr 9;209(4):819-35
pubmed: 22451716
J Thromb Haemost. 2016 Oct;14(10):1908-1916
pubmed: 27513692
Cell Signal. 2015 Jan;27(1):37-46
pubmed: 25283599
Front Biosci (Landmark Ed). 2011 Jun 01;16(8):3156-63
pubmed: 21622226
Int J Cardiol. 2010 Jun 25;142(1):2-7
pubmed: 19906450
Lancet. 1996 Nov 16;348(9038):1329-39
pubmed: 8918275
PLoS One. 2017 Oct 26;12(10):e0186220
pubmed: 29073236
Blood. 2017 Feb 23;129(8):1021-1029
pubmed: 27919911
J Exp Med. 2009 Oct 26;206(11):2365-79
pubmed: 19808257
Atherosclerosis. 2015 Oct;242(2):639-46
pubmed: 25817329
Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1374-81
pubmed: 25908768
J Thromb Haemost. 2010 Jun;8(6):1364-71
pubmed: 20230421
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1977-84
pubmed: 25012129
J Clin Invest. 2015 Dec;125(12):4638-54
pubmed: 26551681
J Pharmacol Exp Ther. 2012 Nov;343(2):253-7
pubmed: 22837011
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006429
pubmed: 22315715
J Thromb Haemost. 2010 Jun;8(6):1295-301
pubmed: 20796202
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2787-92
pubmed: 16990551
J Vasc Surg. 2007 Jan;45 Suppl S:S5-67
pubmed: 17223489
Thromb Haemost. 2017 Jun 28;117(7):1379-1390
pubmed: 28492698
Cell Mol Life Sci. 2008 Mar;65(5):713-27
pubmed: 18193161
Nature. 1998 Feb 5;391(6667):591-4
pubmed: 9468137
Nat Med. 2019 Aug;25(8):1274-1279
pubmed: 31285632
Circulation. 2018 Oct 16;138(16):1706-1719
pubmed: 29700120
N Engl J Med. 2001 Oct 4;345(14):1022-9
pubmed: 11586954
N Engl J Med. 2012 Jan 5;366(1):9-19
pubmed: 22077192
Int J Cardiol. 2018 Jun 1;260:11-15
pubmed: 29530620
Hamostaseologie. 2015;35(2):121-7
pubmed: 25385255
Blood. 2020 Mar 5;135(10):755-765
pubmed: 31971571
J Blood Med. 2010;1:197-219
pubmed: 22282698
Biochemistry. 1996 Feb 13;35(6):1904-10
pubmed: 8639673
Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1642-8
pubmed: 12377743
Drugs. 2022 Aug;82(12):1287-1302
pubmed: 35997941
Blood. 1994 Jul 15;84(2):390-6
pubmed: 8025267
Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1674-80
pubmed: 24855058
J Thromb Haemost. 2012 Jul;10(7):1207-16
pubmed: 22578148
Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1187-92
pubmed: 24675658
Thromb Haemost. 2016 Sep 27;116(4):605-12
pubmed: 27384503
J Am Coll Cardiol. 2005 Sep 20;46(6):937-54
pubmed: 16168274
Blood. 2011 Sep 29;118(13):3708-14
pubmed: 21700775
J Thromb Haemost. 2012 Jul;10(7):1355-62
pubmed: 22537188
Vasc Health Risk Manag. 2009;5(1):185-97
pubmed: 19436645
Mediators Inflamm. 2011;2011:432080
pubmed: 21772662
J Am Coll Cardiol. 2015 Oct 13;66(15):1643-53
pubmed: 26449133
Eur Heart J. 2015 Jun 7;36(22):1405-14
pubmed: 25660055
Nature. 2000 Sep 14;407(6801):258-64
pubmed: 11001069
Stroke. 2006 May;37(5):1195-9
pubmed: 16574926
Nat Med. 2007 Sep;13(9):1086-95
pubmed: 17721545
Thromb Haemost. 2014 Jan;111(1):140-53
pubmed: 24136115
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2554-61
pubmed: 26471268
Blood. 2006 Apr 1;107(7):2728-35
pubmed: 16357324
Science. 2015 Jul 17;349(6245):316-20
pubmed: 26185250
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2424-33
pubmed: 21071692
N Engl J Med. 2020 May 21;382(21):1994-2004
pubmed: 32222135
N Engl J Med. 2011 May 5;364(18):1746-60
pubmed: 21542745
Thromb Haemost. 2013 Aug;110(2):233-43
pubmed: 23784703
Semin Thromb Hemost. 2017 Nov;43(8):814-826
pubmed: 28346966
Eur Heart J. 2017 Jul 01;38(25):1993-2005
pubmed: 28431006
Semin Hematol. 2007 Apr;44(2):106-13
pubmed: 17433903
Eur Heart J. 2018 Jun 7;39(22):2070-2076
pubmed: 29329384
Front Cardiovasc Med. 2018 Apr 06;5:36
pubmed: 29682509
Nat Commun. 2017 Feb 20;8:14151
pubmed: 28218242
Front Physiol. 2014 Aug 08;5:294
pubmed: 25152735
Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2018-2032
pubmed: 32640905
Adv Immunol. 2016;129:25-53
pubmed: 26791857
Immunity. 2014 Nov 20;41(5):694-707
pubmed: 25517612
J Thromb Thrombolysis. 2016 Aug;42(2):225-32
pubmed: 27007282
Blood. 2015 Apr 23;125(17):2693-703
pubmed: 25710879
N Engl J Med. 2017 Oct 5;377(14):1319-1330
pubmed: 28844192
Nat Med. 2009 Nov;15(11):1318-21
pubmed: 19855397
Blood. 2017 Feb 16;129(7):883-895
pubmed: 28034890
Vasc Med. 2019 Oct;24(5):414-421
pubmed: 31277561
PLoS One. 2013;8(2):e55784
pubmed: 23409043
Blood. 2011 Aug 18;118(7):1952-61
pubmed: 21673343
Eur Heart J. 2017 Jan 1;38(1):38-50
pubmed: 27071821
Physiol Rev. 2004 Apr;84(2):579-621
pubmed: 15044683
Indian Heart J. 2019 Jan - Feb;71(1):15-24
pubmed: 31000178
Thromb Haemost. 2014 Jun;111(6):1089-101
pubmed: 24499865
J Thromb Haemost. 2011 Sep;9(9):1835-46
pubmed: 21696539
FASEB J. 2002 Dec;16(14):1903-16
pubmed: 12468455
Blood. 2016 Aug 11;128(6):753-62
pubmed: 27354721
Sci Rep. 2019 Mar 7;9(1):3909
pubmed: 30846818
Semin Thromb Hemost. 2019 Feb;45(1):86-93
pubmed: 30634198
Blood. 2002 Sep 1;100(5):1707-14
pubmed: 12176891