Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?
Hypoxia
Normoxia
Oncolytic virus
Tumor microenvironment
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
24 Nov 2022
24 Nov 2022
Historique:
received:
29
04
2022
accepted:
01
11
2022
entrez:
24
11
2022
pubmed:
25
11
2022
medline:
25
11
2022
Statut:
epublish
Résumé
Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outcome of viral pathogenicity. One of the important factors influencing cells or the outcome of viral infection is the level of oxygen. Recently, oncolytic virotherapy has attracted attention as a promising approach to improving cancer treatment. However, it was shown that tumor cells are mostly less oxygenated compared with their normal counterparts, which might affect the outcome of oncolytic virotherapy. Therefore, knowing how oncolytic viruses could cope with stressful environments, particularly hypoxic environments, might be essential for improving oncolytic virotherapy.
Identifiants
pubmed: 36424577
doi: 10.1186/s12935-022-02774-w
pii: 10.1186/s12935-022-02774-w
pmc: PMC9686061
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
370Informations de copyright
© 2022. The Author(s).
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