Triple tSMS system ("SHIN jiba") for non-invasive deep brain stimulation: a validation study in healthy subjects.
Deep brain stimulation
Neodymium magnet
Non-invasive brain stimulation
SHIN jiba
Transcranial static magnetic field stimulation
Journal
Journal of neuroengineering and rehabilitation
ISSN: 1743-0003
Titre abrégé: J Neuroeng Rehabil
Pays: England
ID NLM: 101232233
Informations de publication
Date de publication:
24 11 2022
24 11 2022
Historique:
received:
05
06
2022
accepted:
15
11
2022
entrez:
24
11
2022
pubmed:
25
11
2022
medline:
29
11
2022
Statut:
epublish
Résumé
Transcranial static magnetic field stimulation (tSMS) using a small and strong neodymium (NdFeB) magnet can temporarily suppress brain functions below the magnet. It is a promising non-invasive brain stimulation modality because of its competitive advantages such as safety, simplicity, and low-cost. However, current tSMS is insufficient to effectively stimulate deep brain areas due to attenuation of the magnetic field with the distance from the magnet. The aim of this study was to develop a brand-new tSMS system for non-invasive deep brain stimulation. We designed and fabricated a triple tSMS system with three cylindrical NdFeB magnets placed close to each other. We compared the strength of magnetic field produced by the triple tSMS system with that by the current tSMS. Furthermore, to confirm its function, we stimulated the primary motor area in 17 healthy subjects with the triple tSMS for 20 min and assessed the cortical excitability using the motor evoked potential (MEP) obtained by transcranial magnetic stimulation. Our triple tSMS system produced the magnetic field sufficient for neuromodulation up to 80 mm depth from the magnet surface, which was 30 mm deeper than the current tSMS system. In the stimulation experiment, the triple tSMS significantly reduced the MEP amplitude, demonstrating a successful inhibition of the M1 excitability in healthy subjects. Our triple tSMS system has an ability to produce an effective magnetic field in deep areas and to modulate the brain functions. It can be used for non-invasive deep brain stimulation.
Sections du résumé
BACKGROUND
Transcranial static magnetic field stimulation (tSMS) using a small and strong neodymium (NdFeB) magnet can temporarily suppress brain functions below the magnet. It is a promising non-invasive brain stimulation modality because of its competitive advantages such as safety, simplicity, and low-cost. However, current tSMS is insufficient to effectively stimulate deep brain areas due to attenuation of the magnetic field with the distance from the magnet. The aim of this study was to develop a brand-new tSMS system for non-invasive deep brain stimulation.
METHODS
We designed and fabricated a triple tSMS system with three cylindrical NdFeB magnets placed close to each other. We compared the strength of magnetic field produced by the triple tSMS system with that by the current tSMS. Furthermore, to confirm its function, we stimulated the primary motor area in 17 healthy subjects with the triple tSMS for 20 min and assessed the cortical excitability using the motor evoked potential (MEP) obtained by transcranial magnetic stimulation.
RESULTS
Our triple tSMS system produced the magnetic field sufficient for neuromodulation up to 80 mm depth from the magnet surface, which was 30 mm deeper than the current tSMS system. In the stimulation experiment, the triple tSMS significantly reduced the MEP amplitude, demonstrating a successful inhibition of the M1 excitability in healthy subjects.
CONCLUSION
Our triple tSMS system has an ability to produce an effective magnetic field in deep areas and to modulate the brain functions. It can be used for non-invasive deep brain stimulation.
Identifiants
pubmed: 36424652
doi: 10.1186/s12984-022-01110-7
pii: 10.1186/s12984-022-01110-7
pmc: PMC9694846
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
129Informations de copyright
© 2022. The Author(s).
Références
Prog Biophys Mol Biol. 2016 May;121(1):16-28
pubmed: 26975790
Sci Rep. 2021 Apr 15;11(1):8261
pubmed: 33859297
J Neurosci. 2015 Jun 17;35(24):9182-93
pubmed: 26085640
Neurosci Res. 2020 Jul;156:250-255
pubmed: 31883871
Cell Biochem Biophys. 2003;39(2):163-73
pubmed: 14515021
Neuromodulation. 2014 Jul;17(5):438-41; discussion 441-2
pubmed: 24125470
Sci Rep. 2021 Mar 8;11(1):5370
pubmed: 33686102
Neuromodulation. 2020 Apr;23(3):335-340
pubmed: 31353758
Front Neurosci. 2020 May 19;14:419
pubmed: 32508563
Sci Rep. 2016 Oct 04;6:34509
pubmed: 27698365
J Neurosci. 2017 Apr 5;37(14):3840-3847
pubmed: 28280254
Neuroimage. 2011 Jan 1;54(1):313-27
pubmed: 20656036
Clin Neurophysiol. 2015 Dec;126(12):2314-9
pubmed: 25792074
Nat Rev Neurol. 2019 Mar;15(3):148-160
pubmed: 30683913
Neurosci Lett. 2020 Apr 1;723:134871
pubmed: 32109553
Brain Stimul. 2018 Jul - Aug;11(4):676-688
pubmed: 29500043
Brain Stimul. 2021 Jan-Feb;14(1):51-54
pubmed: 33186779
Clin Neurophysiol. 2012 May;123(5):858-82
pubmed: 22349304
Commun Biol. 2019 Oct 31;2:397
pubmed: 31701026
J Physiol. 2011 Oct 15;589(Pt 20):4949-58
pubmed: 21807616
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Brain Stimul. 2013 Sep;6(5):817-20
pubmed: 23598254
Brain Stimul. 2014 Nov-Dec;7(6):836-40
pubmed: 25444588