Recovering Osteoblast Functionality on TiO
bone surface interactions
cellular nanomodulation
osteoblast regeneration
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
09
2022
accepted:
08
11
2022
entrez:
25
11
2022
pubmed:
26
11
2022
medline:
29
11
2022
Statut:
epublish
Résumé
Titanium (Ti) and its alloys (eg, Ti We evaluated the bone-forming functional properties of osteoblasts on synthesized TiO The diabetic conditions depressed the initial osteoblast growth ability, as evidenced by altered early cell adhesion and reduced proliferation. Nonetheless, after three days, the diabetic damage was suppressed by the NTs, enhancing the osteoblast activity. Therefore, the osteogenic markers of bone formation and the differentiation of osteoblasts were reactivated by the nanoconfigured surfaces. Far more importantly, collagen secretion and bone-matrix mineralization were stimulated and conducted to levels similar to those of the control of FBS conditions, in comparison to the control alloy, which was not able to reach similar levels of bone functionality than the NTs. Our study brings knowledge for the potential application of nanostructured biomaterials to work as an integrative platform under the detrimental metabolic status present in diabetic conditions.
Identifiants
pubmed: 36426372
doi: 10.2147/IJN.S387386
pii: 387386
pmc: PMC9680990
doi:
Substances chimiques
titanium dioxide
15FIX9V2JP
Alloys
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5469-5488Informations de copyright
© 2022 Valdez-Salas et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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