Adipocytokine plasma concentrations reflect influence of inflammation but not body mass index (BMI) on clinical outcomes of COVID-19 patients: A prospective observational study from the Netherlands.
Adipocytokines
BMI
COVID-19
inflammation
obesity
Journal
Clinical obesity
ISSN: 1758-8111
Titre abrégé: Clin Obes
Pays: England
ID NLM: 101560587
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
revised:
21
10
2022
received:
11
07
2022
accepted:
08
11
2022
pubmed:
26
11
2022
medline:
8
3
2023
entrez:
25
11
2022
Statut:
ppublish
Résumé
Obesity is recognized as a risk factor for adverse outcome in COVID-19, but the molecular mechanisms underlying this relationship remain unknown. Adipose tissue functions as an endocrine organ by secreting multiple pro-inflammatory and anti-inflammatory factors, known as adipocytokines, which could be involved in COVID-19 severity. We explored the role of adipocytokines in COVID-19 and its association with BMI, clinical outcome, and inflammation. This is an observational study in 195 hospitalized COVID-19 patients. Serial plasma concentrations of the adipocytokines leptin, adiponectin, resistin, and various inflammatory cytokines were assessed. Adipocytokines were compared between patients with normal weight (BMI: 18.5-24.9 kg/m
Substances chimiques
Adipokines
0
Leptin
0
Resistin
0
Adiponectin
0
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12568Subventions
Organisme : Netherlands Organization for Scientific Research
ID : Spinoza Grant
Organisme : Radboud University Medical Center : Radboud Corona Fund
Organisme : European Research Council
ID : 833247
Pays : International
Informations de copyright
© 2022 The Authors. Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
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