Perspectives in linear accelerator for FLASH VHEE: Study of a compact C-band system.

Particle Accelerators
Dosimetry FLASH effect High electron-beam current linear accelerators Radioprotection Very-high electron energy beams for radiotherapy

Journal

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 02 05 2022
revised: 10 10 2022
accepted: 23 10 2022
pubmed: 26 11 2022
medline: 15 12 2022
entrez: 25 11 2022
Statut: ppublish

Résumé

In order to translate the FLASH effect in clinical use and to treat deep tumors, Very High Electron Energy irradiations could represent a valid technique. Here, we address the main issues in the design of a VHEE FLASH machine. We present preliminary results for a compact C-band system aiming to reach a high accelerating gradient and high current necessary to deliver a Ultra High Dose Rate with a beam pulse duration of 3μs. The proposed system is composed by low energy high current injector linac followed by a high acceleration gradient structure able to reach 60-160 MeV energy range. To obtain the maximum energy, an energy pulse compressor options is considered. CST code was used to define the specifications RF parameters of the linac. To optimize the accelerated current and therefore the delivered dose, beam dynamics simulations was performed using TSTEP and ASTRA codes. The VHEE parameters Linac suitable to satisfy FLASH criteria were simulated. Preliminary results allow to obtain a maximum energy of 160 MeV, with a peak current of 200 mA, which corresponds to a charge of 600 nC. A promising preliminary design of VHEE linac for FLASH RT has been performed. Supplementary studies are on going to complete the characterization of the machine and to manufacture and test the RF prototypes.

Identifiants

DOI: 10.1016/j.ejmp.2022.10.018 PMID: 36427487
pubmed: 36427487
pii: S1120-1797(22)02079-8
doi: 10.1016/j.ejmp.2022.10.018
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

149-159

Informations de copyright

Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.

Auteurs

L Faillace (L)

INFN Laboratori Nazionali di Frascati, Italy. Electronic address: luigi.faillace@lnf.infn.it.

D Alesini (D)

INFN Laboratori Nazionali di Frascati, Italy.

G Bisogni (G)

INFN Sezione di Pisa, Italy; Department of Physics, University of Pisa, 56127 Pisa, Italy.

F Bosco (F)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

M Carillo (M)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

P Cirrone (P)

INFN Laboratori Nazionali del Sud, Catania, Italy.

G Cuttone (G)

INFN Laboratori Nazionali del Sud, Catania, Italy.

D De Arcangelis (D)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

A De Gregorio (A)

INFN Sezione di Roma, Italy; Department of Physics, Sapienza University, Piazzale Aldo Moro 2, 00185 Rome, Italy.

F Di Martino (F)

U.O. Fisica Sanitaria, Azienda Universitaria Ospedaliera Pisana, Pisa, Italy.

V Favaudon (V)

Institut Curie, Paris-Saclay University, PSL Research University, INSERM U1021/UMR3347, Orsay, France.

L Ficcadenti (L)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

D Francescone (D)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

G Franciosini (G)

INFN Sezione di Roma, Italy; Department of Physics, Sapienza University, Piazzale Aldo Moro 2, 00185 Rome, Italy.

A Gallo (A)

INFN Laboratori Nazionali di Frascati, Italy.

S Heinrich (S)

Institut Curie, Paris-Saclay University, PSL Research University, INSERM U1021/UMR3347, Orsay, France.

M Migliorati (M)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

A Mostacci (A)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

L Palumbo (L)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

V Patera (V)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

A Patriarca (A)

Institut Curie, PSL Research University, Proton Therapy Centre, Centre Universitaire, Orsay, France.

J Pensavalle (J)

INFN Sezione di Pisa, Italy; Department of Physics, University of Pisa, 56127 Pisa, Italy.

F Perondi (F)

SBAI Department, Sapienza University of Rome, Italy.

R Remetti (R)

SBAI Department, Sapienza University of Rome, Italy.

A Sarti (A)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

B Spataro (B)

INFN Laboratori Nazionali di Frascati, Italy.

G Torrisi (G)

INFN Laboratori Nazionali del Sud, Catania, Italy.

A Vannozzi (A)

INFN Laboratori Nazionali di Frascati, Italy.

L Giuliano (L)

SBAI Department, Sapienza University of Rome, Italy; INFN Sezione di Roma, Italy.

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Classifications MeSH

questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Accélérateurs de particules › Perspectives in linear accelerator for FLASH...