Noninfectious Pulmonary Complications after Hematopoietic Stem Cell Transplantation.
Hematopoietic stem cell transplantation
Pulmonary complications
Journal
Transplantation and cellular therapy
ISSN: 2666-6367
Titre abrégé: Transplant Cell Ther
Pays: United States
ID NLM: 101774629
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
19
08
2022
revised:
31
10
2022
accepted:
14
11
2022
pubmed:
26
11
2022
medline:
14
2
2023
entrez:
25
11
2022
Statut:
ppublish
Résumé
Pulmonary complications after hematopoietic stem cell transplantation (HSCT) are important sources of morbidity and mortality. Improvements in infection-related complications have made noninfectious pulmonary complications an increasingly significant driver of transplantation-related mortality. Broadly, these complications can be characterized as either early or late complications, with idiopathic pneumonia syndrome and bronchiolitis obliterans syndrome the most prevalent early and late complications, respectively. Outcomes with historical treatment consisting mainly of corticosteroids are often poor, highlighting the need for a deeper understanding of these complications' underlying disease biology to guide the adoption of novel therapies that are being increasingly used in the modern era.
Identifiants
pubmed: 36427785
pii: S2666-6367(22)01778-X
doi: 10.1016/j.jtct.2022.11.012
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-93Informations de copyright
Copyright © 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest T.K.K. has received a research funding from Nextcure, that is not relevant to this manuscript. T.K.K. is a consultant for Agenus and Immunobiome. The other authors have no conflicts of interest to report.