Physins in digestive system neoplasms.

Humans Synaptophysin Pancreatic Neoplasms / pathology Digestive System Neoplasms / diagnosis Neuroendocrine Tumors / diagnosis Prognosis
Colorectal neoplasms Neuroendocrine neoplasms Synaptophysin Synaptophysin like 1 Synaptophysin like 2 Synaptoporin

Journal

Advances in clinical chemistry
ISSN: 2162-9471
Titre abrégé: Adv Clin Chem
Pays: United States
ID NLM: 2985173R

Informations de publication

Date de publication:
2022
Historique:
entrez: 25 11 2022
pubmed: 26 11 2022
medline: 30 11 2022
Statut: ppublish

Résumé

The physin family of proteins, synaptophysin (SYP), synaptophysin like 1 (SYPL1), synaptophysin like 2 (SYPL2) and synaptoporin (SYNRP), are tetratransmembrane transport vesicle proteins distributed throughout the digestive system. Of these, SYP is a required marker for histopathologic identification of neuroendocrine neoplasms (NENs), especially in gastroenteropancreatic NENs (GEP-NENs). Recently, bloodstream SYP, i.e., on platelets and circulating tumor cells, has been correlated to clinicopathologic features of GEP-NENs and may have prognostic significance. Serum SYPL1 also represents a promising biomarker for colorectal cancer. This chapter provides an overview of physin structures and potential use as diagnostic, prognostic and therapeutic tools for digestive tract neoplasms.

Identifiants

DOI: 10.1016/bs.acc.2022.08.002 PMID: 36427909
pubmed: 36427909
pii: S0065-2423(22)00068-3
doi: 10.1016/bs.acc.2022.08.002
pii:
doi:

Substances chimiques

Synaptophysin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

157-176

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Lei Liu (L)

Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu, Sichuan, China.

Xue Yao (X)

School of Medicine, Southwest Jiaotong University, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Yanrong Wang (Y)

Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Ruiqi Hu (R)

Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Chao Fan (C)

School of Medicine, Southwest Jiaotong University, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Hongping Gong (H)

The People's Hospital of Ganzi Tibetan Autonomous Prefecture, Kangding, Sichuan, China.

Jinbo Liu (J)

Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. Electronic address: liulab2019@163.com.

Yuanbiao Guo (Y)

Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu, Sichuan, China. Electronic address: guo.ybiao@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Physins in digestive system neoplasms.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Synaptophysine › Physins in digestive system neoplasms.
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Physins in digestive system neoplasms.
questionsmedicales.fr › Maladies de l'appareil digestif › Tumeurs de l'appareil digestif › Physins in digestive system neoplasms.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Physins in digestive system neoplasms.
questionsmedicales.fr › Diagnostic › Pronostic › Physins in digestive system neoplasms.