Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review.
classical Hodgkin lymphoma
composite lymphoma
lymphomagenesis
plasticity
synchronous lymphoma
transdifferentiation
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
19 Nov 2022
19 Nov 2022
Historique:
received:
12
10
2022
revised:
04
11
2022
accepted:
18
11
2022
entrez:
26
11
2022
pubmed:
27
11
2022
medline:
27
11
2022
Statut:
epublish
Résumé
The co-occurrence of several lymphomas in a patient defines composite/synchronous lymphoma. A common cellular origin has been reported for both contingents of such entities. In the present review, we aimed to gather the available data on composite lymphomas associating a classical Hodgkin lymphoma (cHL) with another lymphoma, to better understand the plasticity of mature B and T-cells. This review highlights that >70% of patients with a composite lymphoma are ≥55 years old, with a male predominance. The most reported associations are cHL with follicular lymphoma or diffuse large B-cell lymphoma, with over 130 cases reported. The cHL contingent is often of mixed cellularity type, with a more frequent focal/weak CD20 expression (30% to 55.6%) compared to de novo cHL, suggesting a particular pathophysiology. Moreover, Hodgkin cells may express specific markers of the associated lymphoma (e.g., BCL2/BCL6 for follicular lymphoma and Cyclin D1 for mantle cell lymphoma), sometimes combined with common BCL2/BCL6 or CCND1 rearrangements, respectively. In addition, both contingents may share similar IgH/IgK rearrangements and identical pathogenic variants, reinforcing the hypothesis of a common clonal origin. Finally, cHL appears to be endowed with a greater plasticity than previously thought, supporting a common clonal origin and a transdifferentiation process during lymphomagenesis of composite lymphomas.
Identifiants
pubmed: 36428786
pii: cancers14225695
doi: 10.3390/cancers14225695
pmc: PMC9688742
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
N Engl J Med. 1999 Apr 22;340(16):1239-47
pubmed: 10210707
Leukemia. 2005 Aug;19(8):1452-8
pubmed: 15973455
Pathology. 2009;41(4):305-26
pubmed: 19404843
Histopathology. 1995 Dec;27(6):491-9
pubmed: 8838328
Int J Surg Pathol. 2012 Apr;20(2):201-4
pubmed: 21813545
Diagn Pathol. 2011 Jul 06;6:60
pubmed: 21733146
Mod Pathol. 1996 Oct;9(10):1020-6
pubmed: 8902841
Am J Surg Pathol. 1993 Apr;17(4):364-74
pubmed: 8494105
Clin Adv Hematol Oncol. 2015 Apr;13(4):257-60
pubmed: 26352584
Zhonghua Yi Xue Za Zhi. 2016 Jul 26;96(28):2224-8
pubmed: 27480653
Curr Oncol. 2021 Sep 06;28(5):3430-3447
pubmed: 34590593
Cancer. 1991 Mar 15;67(6):1622-8
pubmed: 2001551
Blood. 2002 Aug 15;100(4):1425-9
pubmed: 12149227
Pathol Int. 2017 Apr;67(4):194-201
pubmed: 28191697
J Pediatr Hematol Oncol. 2022 May 1;44(4):e833-e843
pubmed: 35398861
Leuk Lymphoma. 2012 Nov;53(11):2302-3
pubmed: 22432520
J Pathol. 1993 Jul;170(3):239-48
pubmed: 8133397
Cancer. 1990 Aug 15;66(4):796-800
pubmed: 2167145
Am J Clin Pathol. 1993 Jun;99(6):658-62
pubmed: 8322699
Ann Palliat Med. 2020 Sep;9(5):3651-3662
pubmed: 32921109
Ann Hematol. 2018 Feb;97(2):355-357
pubmed: 28975389
Mol Med. 2001 May;7(5):285-92
pubmed: 11474574
Clin Med Insights Blood Disord. 2016 Aug 03;9:23-8
pubmed: 27512341
N Engl J Med. 2000 Oct 12;343(15):1124-5
pubmed: 11032527
Ann Diagn Pathol. 2002 Feb;6(1):61-6
pubmed: 11842381
Blood. 2011 Jul 21;118(3):493-8
pubmed: 21562039
Hum Pathol. 2013 Jul;44(7):1434-9
pubmed: 23427872
J Med Case Rep. 2021 Apr 14;15(1):163
pubmed: 33849639
Am J Surg Pathol. 1999 Oct;23(10):1233-40
pubmed: 10524524
N Engl J Med. 1992 Apr 23;326(17):1115-22
pubmed: 1532439
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Indian J Pathol Microbiol. 2019 Jul-Sep;62(3):488-490
pubmed: 31361250
Pathol Int. 2021 Jan;71(1):96-101
pubmed: 33079423
Am J Clin Pathol. 2011 Apr;135(4):541-55
pubmed: 21411776
Pathol Res Pract. 2015 Jan;211(1):83-7
pubmed: 25434605
Diagn Mol Pathol. 2002 Mar;11(1):2-8
pubmed: 11854595
Pathol Res Pract. 2016 Dec;212(12):1179-1190
pubmed: 27887763
Histopathology. 2011 Aug;59(2):352-5
pubmed: 21884219
Yonsei Med J. 1991 Dec;32(4):362-9
pubmed: 1812658
J Exp Med. 2000 Jan 17;191(2):387-94
pubmed: 10637283
Jpn J Clin Oncol. 2015 Oct;45(10):921-8
pubmed: 26206898
Am J Surg Pathol. 2011 May;35(5):767-72
pubmed: 21490448
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14920-5
pubmed: 19706467
Br J Haematol. 2020 Apr;189(2):244-256
pubmed: 32030731
Pathol Int. 2012 Aug;62(8):518-24
pubmed: 22827759
Indian J Cancer. 2017 Jan-Mar;54(1):358-361
pubmed: 29199722
Am J Surg Pathol. 2022 Aug 25;:
pubmed: 36001451
J Am Soc Echocardiogr. 2010 Oct;23(10):1113.e5-7
pubmed: 20451348
Exp Mol Med. 2015 Jan 23;47:e131
pubmed: 25613728
Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):8-14
pubmed: 28549034
Leuk Lymphoma. 2001 Jul;42(3):543-9
pubmed: 11699423
Tanaffos. 2014;13(2):47-9
pubmed: 25506376
Haematologica. 2011 Apr;96(4):558-66
pubmed: 21454882
Virchows Arch A Pathol Anat Histopathol. 1992;421(3):271-5
pubmed: 1384224
Int J Surg Pathol. 2017 May;25(3):281-286
pubmed: 27829209
Am J Clin Pathol. 2004 May;121(5):701-8
pubmed: 15151210
Cancer. 1977 Sep;40(3):959-76
pubmed: 332325
Tohoku J Exp Med. 2021;254(2):123-127
pubmed: 34193763
Am J Surg Pathol. 2005 Nov;29(11):1411-21
pubmed: 16224207
World J Gastroenterol. 2013 Oct 7;19(37):6304-9
pubmed: 24115832
Int J Cancer. 2014 Feb 15;134(4):832-43
pubmed: 23929122
Nat Rev Cancer. 2005 Apr;5(4):251-62
pubmed: 15803153
J Am Geriatr Soc. 2015 Apr;63(4):824-6
pubmed: 25900501
J Pathol. 2000 Aug;191(4):394-9
pubmed: 10918214
Leuk Res Rep. 2021 Apr 08;15:100240
pubmed: 33936943
Am J Hematol. 1983 Jun;14(4):355-62
pubmed: 6687977
Cardiovasc Hematol Disord Drug Targets. 2020;20(2):160-163
pubmed: 31633478
Arch Pathol Lab Med. 1996 Apr;120(4):386-9
pubmed: 8619752
Pathol Int. 2020 Nov;70(11):893-898
pubmed: 32881147
J Hematop. 2009 Dec 22;2(4):211-36
pubmed: 20309430
Pediatr Dev Pathol. 2004 Jul-Aug;7(4):348-60
pubmed: 14564542
Arch Pathol Lab Med. 2000 Jun;124(6):907-9
pubmed: 10835534
J Pathol Transl Med. 2022 Jan;56(1):57-60
pubmed: 34775730
Mod Pathol. 1998 May;11(5):485-90
pubmed: 9619603
Br J Haematol. 2015 Aug;170(3):428-31
pubmed: 25715982
Open Med (Wars). 2020 Jul 10;15(1):654-658
pubmed: 33336022
J Clin Exp Hematop. 2007 Apr;47(1):9-13
pubmed: 17510532
Blood. 2000 May 15;95(10):3020-4
pubmed: 10807764
J La State Med Soc. 2004 Nov-Dec;156(6):294-7
pubmed: 15688668
Am J Surg Pathol. 2022 Jan 1;46(1):58-70
pubmed: 34265801
Clin Case Rep. 2018 Oct 22;6(12):2341-2346
pubmed: 30564326
Haematologica. 2016 Jul;101(7):853-60
pubmed: 27365461
Ann Oncol. 2017 Nov 01;28(11):2799-2805
pubmed: 29045517
Am J Clin Pathol. 1991 Jul;96(1):81-9
pubmed: 2069139
Best Pract Res Clin Haematol. 2017 Mar - Jun;30(1-2):5-12
pubmed: 28288716
Int J Cancer. 2018 Oct 15;143(8):2076-2078
pubmed: 29708584
Blood. 2015 Oct 22;126(17):1990-5
pubmed: 26311361
J Clin Oncol. 2013 Mar 1;31(7):938-43
pubmed: 23284040
N Engl J Med. 1999 Sep 2;341(10):764-5
pubmed: 10475800
Histopathology. 2006 Apr;48(5):621-3
pubmed: 16623796
Am J Surg Pathol. 2013 Jun;37(6):816-26
pubmed: 23598959
Blood. 2008 Jun 15;111(12):5433-9
pubmed: 18272816
Int J Lab Hematol. 2007 Dec;29(6):461-3
pubmed: 17988302
Blood. 1994 Jan 1;83(1):223-30
pubmed: 8274737
Acta Derm Venereol. 2009;89(4):421-2
pubmed: 19688163
Lancet Oncol. 2014 Sep;15(10):e435-46
pubmed: 25186047
Am J Surg Pathol. 2004 May;28(5):679-86
pubmed: 15105659
Am J Surg Pathol. 2022 Jun 1;46(6):793-800
pubmed: 35067515
Am J Surg Pathol. 1992 Sep;16(9):859-67
pubmed: 1384376
Leuk Res. 2021 Dec;111:106669
pubmed: 34333276
Int J Surg Case Rep. 2018;46:50-55
pubmed: 29684805
Case Rep Hematol. 2018 Aug 2;2018:4312594
pubmed: 30155322
Am J Pathol. 1990 Jan;136(1):81-94
pubmed: 2297052
Histopathology. 2011 Jan;58(1):15-25
pubmed: 21261680
Lab Invest. 2004 Feb;84(2):253-62
pubmed: 14688797
Eur J Pediatr. 2016 Apr;175(4):593-7
pubmed: 26526666
Rom J Morphol Embryol. 2010;51(2):353-8
pubmed: 20495755
Haematologica. 2011 Feb;96(2):262-8
pubmed: 20971819
Histopathology. 1989 Jul;15(1):35-48
pubmed: 2548946
Am J Surg Pathol. 1996 Mar;20(3):355-62
pubmed: 8772790
Ann Diagn Pathol. 2008 Jun;12(3):212-6
pubmed: 18486899
J Clin Oncol. 2002 Mar 1;20(5):1278-87
pubmed: 11870170
Am J Surg Pathol. 2003 Nov;27(11):1483-8
pubmed: 14576485
J Clin Med Res. 2017 Mar;9(3):213-215
pubmed: 28179969
Am J Surg Pathol. 1994 Jan;18(1):48-61
pubmed: 8279628
Pediatr Blood Cancer. 2020 May;67(5):e28206
pubmed: 32037692
Am J Clin Pathol. 2004 Dec;122(6):858-64
pubmed: 15539378
Lab Invest. 2002 Sep;82(9):1103-9
pubmed: 12218070
J Cancer Res Ther. 2011 Oct-Dec;7(4):484-5
pubmed: 22269415
Virchows Arch. 2005 Oct;447(4):778-80
pubmed: 15983819
Int J Hematol. 2018 Jun;107(6):703-708
pubmed: 29177642
BMJ. 2021 Mar 29;372:n160
pubmed: 33781993
Blood. 2000 Feb 1;95(3):1023-31
pubmed: 10648418
Int J Hematol Oncol Stem Cell Res. 2014 Oct 1;8(4):45-8
pubmed: 25774267
Histopathology. 2005 Feb;46(2):217-28
pubmed: 15693895
Leuk Lymphoma. 2005 Feb;46(2):285-8
pubmed: 15621815
Cancer. 1980 Dec 1;46(11):2505-8
pubmed: 7438022
J Cancer. 2015 Sep 15;6(11):1155-9
pubmed: 26516364
Arch Pathol Lab Med. 2000 Sep;124(9):1376-8
pubmed: 10975943
Am J Clin Pathol. 2006 Aug;126(2):222-9
pubmed: 16891197
Blood. 2002 Jan 15;99(2):690-3
pubmed: 11781255
Diagn Cytopathol. 2017 Mar;45(3):262-266
pubmed: 27888658
Leukemia. 2021 Apr;35(4):968-981
pubmed: 33686198
Blood. 2014 Sep 4;124(10):1563-9
pubmed: 25024303
Am J Surg Pathol. 2012 Nov;36(11):1636-46
pubmed: 23073322
J Clin Pathol. 2004 Mar;57(3):329-31
pubmed: 14990612
Arch Pathol Lab Med. 2006 Jan;130(1):107-12
pubmed: 16390224
Auris Nasus Larynx. 2004 Mar;31(1):89-93
pubmed: 15041061
Semin Diagn Pathol. 1992 Nov;9(4):297-303
pubmed: 1480852
Pathol Int. 2010 Jul;60(7):520-3
pubmed: 20594274
Appl Immunohistochem Mol Morphol. 2009 Jan;17(1):72-6
pubmed: 19115485
J Cutan Pathol. 2020 Sep;47(9):829-833
pubmed: 32285466
Cancer. 1979 Oct;44(4):1408-13
pubmed: 498018
Blood. 2015 Oct 29;126(18):2118-27
pubmed: 26307535
Leuk Lymphoma. 2004 May;45(5):1071-6
pubmed: 15291370
Am J Surg Pathol. 2003 Dec;27(12):1577-80
pubmed: 14657719
Ann Oncol. 1994;5 Suppl 1:7-11
pubmed: 8172822
Hum Pathol. 2011 Jul;42(7):1042-6
pubmed: 21315416