D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review.
D-dimer
ISO15189
In Vitro Diagnostic Regulation
analytical
post-analytical
pre-analytical
pulmonary embolism
venous thromboembolism
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
12 Nov 2022
12 Nov 2022
Historique:
received:
27
09
2022
revised:
08
11
2022
accepted:
09
11
2022
entrez:
26
11
2022
pubmed:
27
11
2022
medline:
27
11
2022
Statut:
epublish
Résumé
D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.
Identifiants
pubmed: 36428830
pii: diagnostics12112770
doi: 10.3390/diagnostics12112770
pmc: PMC9689068
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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