Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor.

Humans AMP-Activated Protein Kinases / metabolism Cell Hypoxia / physiology Hydrogen Peroxide Hypoxia / metabolism Hypoxia-Inducible Factor 1 / metabolism Fatty Acids / metabolism Adenosine Triphosphate / metabolism
1,2-13C2-labelled glucose AMP-activated kinase HIF-1β deficiency Hepa-1 c4 cells PGC-1α PPARα TCA fatty acid oxidation hypoxia response phospho-p38 MAPK

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
14 11 2022
Historique:
received: 15 10 2022
revised: 09 11 2022
accepted: 09 11 2022
entrez: 26 11 2022
pubmed: 27 11 2022
medline: 30 11 2022
Statut: epublish

Résumé

The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and molecular adaptations of HIF-1β-deficient Hepa-1c4, a hepatoma model lacking HIF1/2 signalling, which mimics a cancer treated by a totally effective anti-HIF1/2 agent. [1,2-

Identifiants

DOI: 10.3390/cells11223595 PMID: 36429023 PMC: PMC9688062
pubmed: 36429023
pii: cells11223595
doi: 10.3390/cells11223595
pmc: PMC9688062
pii:
doi:

Substances chimiques

AMP-Activated Protein Kinases EC 2.7.11.31
Hydrogen Peroxide BBX060AN9V
Hypoxia-Inducible Factor 1 0
Fatty Acids 0
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Cancer Research UK
ID : 11359
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C14303/A17197
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C9545/A29580
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C9545/A17197
Pays : United Kingdom

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Auteurs

Monika A Golinska (MA)

Cancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
ORCID: 0000-0003-3679-8782

Marion Stubbs (M)

Cancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

Adrian L Harris (AL)

Hypoxia and Angiogenesis Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK.
ORCID: 0000-0003-1376-8409

Laszlo G Boros (LG)

Department of Pediatrics, Harbor-UCLA Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90502, USA.
SiDMAP, LLC, and the Deutenomics Science Institute, 2990 S. Sepulveda BLVD. #300B, Culver City, CA 90064, USA.
The Lundquist Institute for Biomedical Innovation at the Harbor-UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA.
Submolecular Medical Sciences, Vrije University of Amsterdam, 1081 HV Amsterdam, The Netherlands.

Madhu Basetti (M)

Cancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
ORCID: 0000-0001-5844-856X

Dominick J O McIntyre (DJO)

Cancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

John R Griffiths (JR)

Cancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
ORCID: 0000-0001-7369-6836

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › Lipides › Acides gras › Survival Pathways of HIF-Deficient Tumour...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Survival Pathways of HIF-Deficient Tumour...