Vestibular Nuclei: A New Neural Stem Cell Niche?
neurogenesis
stem cells
vestibular nuclei
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
14 11 2022
14 11 2022
Historique:
received:
29
09
2022
revised:
06
11
2022
accepted:
10
11
2022
entrez:
26
11
2022
pubmed:
27
11
2022
medline:
30
11
2022
Statut:
epublish
Résumé
We previously reported adult reactive neurogliogenesis in the deafferented vestibular nuclei following unilateral vestibular neurectomy (UVN) in the feline and the rodent model. Recently, we demonstrated that UVN induced a significant increase in a population of cells colocalizing the transcription factor sex determining region Y-box 2 (SOX2) and the glial fibrillary acidic protein (GFAP) three days after the lesion in the deafferented medial vestibular nucleus. These two markers expressed on the same cell population could indicate the presence of lesion-reactive multipotent neural stem cells in the vestibular nuclei. The aim of our study was to provide insight into the potential neurogenic niche status of the vestibular nuclei in physiological conditions by using specific markers of stem cells (Nestin, SOX2, GFAP), cell proliferation (BrdU) and neuronal differentiation (NeuN). The present study confirmed the presence of quiescent and activated adult neural stem cells generating some new neurons in the vestibular nuclei of control rats. These unique features provide evidence that the vestibular nuclei represent a novel NSC site for the generation of neurons and/or glia in the adult rodent under physiological conditions.
Identifiants
pubmed: 36429025
pii: cells11223598
doi: 10.3390/cells11223598
pmc: PMC9688605
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Neural Regen Res. 2015 Sep;10(9):1463-70
pubmed: 26604908
Sci Rep. 2017 Jul 21;7(1):6137
pubmed: 28733588
Brain Struct Funct. 2014 Jul;219(4):1385-403
pubmed: 23681169
Biochem Pharmacol. 2017 Oct 1;141:4-22
pubmed: 28690140
Cell Mol Life Sci. 2016 Dec;73(24):4661-4674
pubmed: 27475964
J Exp Neurosci. 2019 Jun 27;13:1179069519856876
pubmed: 31285654
Neuron. 2011 May 26;70(4):687-702
pubmed: 21609825
Stem Cells. 2007 May;25(5):1298-306
pubmed: 17272497
Prog Neurobiol. 2021 Jan;196:101899
pubmed: 32858093
Cells. 2021 Dec 01;10(12):
pubmed: 34943885
Neurosci Lett. 2012 Mar 28;513(1):1-5
pubmed: 22342907
Stem Cells Dev. 2020 May 1;29(9):544-554
pubmed: 31910108
Biol Psychiatry. 2008 Apr 1;63(7):650-5
pubmed: 18067877
Cold Spring Harb Perspect Biol. 2016 Mar 01;8(3):a025981
pubmed: 26931327
J Histochem Cytochem. 2010 Aug;58(8):721-30
pubmed: 20421592
J Neurosci. 2016 Jun 8;36(23):6199-212
pubmed: 27277799
Front Mol Neurosci. 2019 Apr 12;12:85
pubmed: 31031591
Cell Mol Neurobiol. 2014 Jul;34(5):631-42
pubmed: 24744125
Front Neurosci. 2019 Jun 18;13:588
pubmed: 31275097
Neurosci Lett. 2014 Jan 13;558:180-5
pubmed: 24269984
Stem Cells. 2007 Sep;25(9):2146-57
pubmed: 17569787
Neuron. 2019 Dec 4;104(5):834-848
pubmed: 31805262
Dev Cell. 2015 Feb 23;32(4):435-46
pubmed: 25710530
Neuroscience. 2009 Dec 29;164(4):1444-56
pubmed: 19782724
J Neurosci. 2018 Apr 18;38(16):3880-3889
pubmed: 29530987
PLoS One. 2011;6(8):e22262
pubmed: 21853029
Neuroscience. 2006;138(1):5-16
pubmed: 16338085
Cells. 2022 Feb 16;11(4):
pubmed: 35203333
Cell Stem Cell. 2019 May 2;24(5):690-705
pubmed: 31051133
Nat Rev Neurosci. 2007 Jun;8(6):481-8
pubmed: 17514200
J Comp Neurol. 2007 Nov 10;505(2):209-20
pubmed: 17853440
Mol Neurobiol. 2021 Feb;58(2):719-734
pubmed: 33011856
Prog Neurobiol. 2009 May;88(1):41-63
pubmed: 19428961
Cells. 2022 Sep 26;11(19):
pubmed: 36230964
J Neurosci. 2013 Sep 25;33(39):15555-66
pubmed: 24068822
Prog Neurobiol. 2019 Mar;174:28-35
pubmed: 30658127
Eur J Neurosci. 2007 Jan;25(1):47-58
pubmed: 17241266
Cell. 1999 Jun 11;97(6):703-16
pubmed: 10380923
Cell Prolif. 2013 Apr;46(2):137-45
pubmed: 23510468