Evaluation of Auranofin Loading within Ferritin Nanocages.
anticancer activity
ferritin encapsulation
gold compounds
metal complex
metallodrugs
protein metalation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Nov 2022
16 Nov 2022
Historique:
received:
30
09
2022
revised:
02
11
2022
accepted:
14
11
2022
entrez:
26
11
2022
pubmed:
27
11
2022
medline:
30
11
2022
Statut:
epublish
Résumé
Auranofin (AF), a gold(I) compound that is currently used for the treatment of rheumatoid arthritis and is in clinical trials for its promising anticancer activity, was encapsulated within the human H-chain and the horse spleen ferritin nanocages using the alkaline disassembly/reassembly protocol. The aim of the work was to highlight possible differences in their drug loading capacity and efficacy. The drug-loaded ferritins were characterized via UV-vis absorption spectroscopy and inductively coupled plasma-atomic emission spectroscopy to assess AF encapsulation and to define the exact amount of gold atoms trapped in the Ft cavity. The crystal structures allowed us to define the nature of AF interaction with both ferritins and to identify the gold binding sites. Moreover, the biological characterization let us to obtain preliminary information on the cytotoxic effect of AF when bound to the human H-chain.
Identifiants
pubmed: 36430642
pii: ijms232214162
doi: 10.3390/ijms232214162
pmc: PMC9695178
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Auranofin
3H04W2810V
Ferritins
9007-73-2
Gold
7440-57-5
Nanoparticle Drug Delivery System
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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