Association between total body bone mineral density and periodontitis: A Mendelian randomization study.
Mendelian randomization
periodontitis
total body bone mineral density
Journal
Journal of periodontology
ISSN: 1943-3670
Titre abrégé: J Periodontol
Pays: United States
ID NLM: 8000345
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
08
11
2022
received:
20
04
2022
accepted:
08
11
2022
medline:
22
6
2023
pubmed:
27
11
2022
entrez:
26
11
2022
Statut:
ppublish
Résumé
The purpose of the study was to examine the association between total body bone mineral density (BMD) and periodontitis using Mendelian randomization (MR) analysis. We used 81 single nucleotide polymorphisms (SNPs) associated with BMD at a p-value of < 5 × 10 MR showed no association between BMD and periodontitis (odds ratio per standard deviation increment in genetically predicted BMD = 1.00; 95% confidence interval: 0.92-1.08). Leave-one-out analyses and pleiotropy-robust methods did not indicate any bias. The MR study provided no evidence that BMD might be causally linked to periodontitis. Hence it may be concluded as the key finding that BMD depletion does not increase the risk of periodontitis.
Sections du résumé
BACKGROUND
The purpose of the study was to examine the association between total body bone mineral density (BMD) and periodontitis using Mendelian randomization (MR) analysis.
METHODS AND MATERIALS
We used 81 single nucleotide polymorphisms (SNPs) associated with BMD at a p-value of < 5 × 10
RESULTS
MR showed no association between BMD and periodontitis (odds ratio per standard deviation increment in genetically predicted BMD = 1.00; 95% confidence interval: 0.92-1.08). Leave-one-out analyses and pleiotropy-robust methods did not indicate any bias.
CONCLUSIONS
The MR study provided no evidence that BMD might be causally linked to periodontitis. Hence it may be concluded as the key finding that BMD depletion does not increase the risk of periodontitis.
Identifiants
pubmed: 36433673
doi: 10.1002/JPER.22-0249
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
777-784Informations de copyright
© 2022 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.
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