Structural and functional magnetic resonance imaging correlates of fatigue and dual-task performance in progressive multiple sclerosis.

Humans Multiple Sclerosis / complications Task Performance and Analysis Brain / pathology Brain Mapping Multiple Sclerosis, Chronic Progressive / diagnostic imaging Magnetic Resonance Imaging

Atrophy Dual-task Fatigue MRI Multiple sclerosis Resting state Tractography

Journal

Journal of neurology

ISSN: 1432-1459

Titre abrégé: J Neurol

Pays: Germany

ID NLM: 0423161

Informations de publication

Date de publication:
Mar 2023

Historique:

received: 28 09 2022

accepted: 10 11 2022

revised: 09 11 2022

pubmed: 28 11 2022

medline: 3 3 2023

entrez: 27 11 2022

Statut: ppublish

Résumé

Frontal cortico-subcortical dysfunction may contribute to fatigue and dual-task impairment of walking and cognition in progressive multiple sclerosis (PMS). To explore the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in PMS. Brain 3 T structural and functional MRI sequences, Modified Fatigue Impact Scale (MFIS), dual-task motor and cognitive performances were obtained from 57 PMS patients and 10 healthy controls (HC). The associations of thalamic, caudate nucleus and dorsolateral prefrontal cortex (DLPFC) atrophy, microstructural abnormalities of their connections and their resting state effective connectivity (RS-EC) with fatigue and dual-task performance were investigated using random forest. Thirty-seven PMS patients were fatigued (F) (MFIS ≥ 38). Compared to HC, non-fatigued (nF) and F-PMS patients had significantly worse dual-task performance (p ≤ 0.002). Predictors of fatigue (out-of-bag [OOB]-accuracy = 0.754) and its severity (OOB-R In PMS, structural and functional frontal cortico-subcortical abnormalities contribute to fatigue and worse dual-task performance, with different patterns according to the presence of fatigue.

Sections du résumé

BACKGROUND BACKGROUND

Frontal cortico-subcortical dysfunction may contribute to fatigue and dual-task impairment of walking and cognition in progressive multiple sclerosis (PMS).

PURPOSE OBJECTIVE

To explore the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in PMS.

METHODS METHODS

Brain 3 T structural and functional MRI sequences, Modified Fatigue Impact Scale (MFIS), dual-task motor and cognitive performances were obtained from 57 PMS patients and 10 healthy controls (HC). The associations of thalamic, caudate nucleus and dorsolateral prefrontal cortex (DLPFC) atrophy, microstructural abnormalities of their connections and their resting state effective connectivity (RS-EC) with fatigue and dual-task performance were investigated using random forest.

RESULTS RESULTS

Thirty-seven PMS patients were fatigued (F) (MFIS ≥ 38). Compared to HC, non-fatigued (nF) and F-PMS patients had significantly worse dual-task performance (p ≤ 0.002). Predictors of fatigue (out-of-bag [OOB]-accuracy = 0.754) and its severity (OOB-R

CONCLUSIONS CONCLUSIONS

In PMS, structural and functional frontal cortico-subcortical abnormalities contribute to fatigue and worse dual-task performance, with different patterns according to the presence of fatigue.

Identifiants

DOI: 10.1007/s00415-022-11486-0 PMID: 36436069

pubmed: 36436069

doi: 10.1007/s00415-022-11486-0

pii: 10.1007/s00415-022-11486-0

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1543-1563

Subventions

Organisme : Multiple Sclerosis Society of Canada

ID : #EGID3185

Informations de copyright

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