Neuro-vascular coupling and heart rate variability in patients with type II diabetes at different stages of diabetic retinopathy.
diabetes type II
diabetic retinopathy
functional hyperemia
heart rate variability
neuro-vascular coupling
retinal blood flow
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
08
2022
accepted:
26
10
2022
entrez:
28
11
2022
pubmed:
29
11
2022
medline:
29
11
2022
Statut:
epublish
Résumé
There is evidence that diabetes is accompanied by a break-down of functional hyperemia, an intrinsic mechanism of neural tissues to adapt blood flow to changing metabolic demands. However, to what extent functional hyperemia is altered in different stages of diabetic retinopathy (DR) in patients with type II diabetes is largely unknown. The current study set out to investigate flicker-induced retinal blood flow changes in patients with type II diabetes at different stages of DR. A total of 76 subjects were included in the present parallel-group study, of which 56 had diabetes with either no DR or different stages of non-proliferative DR ( In healthy controls, retinal blood flow increased by 40.4 ± 27.2% during flicker stimulation. Flicker responses in patients with DR were significantly decreased depending on the stage of the disease (no DR 37.7 ± 26.0%, mild DR 26.2 ± 28.2%, moderate to severe DR 22.3 ± 13.9%; Our study indicates that flicker induced hyperemia is reduced in patients with DR compared to healthy subjects. Further, this impairment is more pronounced with increasing severity of DR. Further studies are needed to elucidate mechanisms behind the reduced hyperemic response in patients with type II diabetes. [https://clinicaltrials.gov/], identifier [NCT03 552562].
Identifiants
pubmed: 36438055
doi: 10.3389/fmed.2022.1025853
pmc: PMC9684184
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1025853Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 721
Pays : Austria
Informations de copyright
Copyright © 2022 Hommer, Kallab, Schlatter, Janku, Werkmeister, Howorka, Schmidl, Schmetterer and Garhöfer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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