Improved Subcutaneous Delivery of Ketoconazole Using EpiDerm and HSPiP Software-Based Simulations as Assessed by Cell Viability, Cellular Uptake, Permeation, and Hemolysis


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
22 Nov 2022
Historique:
received: 21 09 2022
accepted: 28 10 2022
entrez: 28 11 2022
pubmed: 29 11 2022
medline: 29 11 2022
Statut: epublish

Résumé

Ketoconazole (KETO) is the drug of choice to control local, systemic, and resistant types of fungal infections. Subcutaneous (sub-Q) delivery offers several benefits. The present study investigated the sub-Q delivery of KETO using HSPiP software based on optimized concentrations of dimethylacetamide (DMA) in binary solvents (DMA + water),

Identifiants

pubmed: 36440147
doi: 10.1021/acsomega.2c06001
pmc: PMC9685774
doi:

Types de publication

Journal Article

Langues

eng

Pagination

42593-42606

Informations de copyright

© 2022 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Afzal Hussain (A)

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh11451, Saudi Arabia.

Obaid Afzal (O)

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj11942, Saudi Arabia.

Mohammad A Altamimi (MA)

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh11451, Saudi Arabia.

Abdulmalik Saleh Alfawaz Altamimi (AS)

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj11942, Saudi Arabia.

Mohhammad Ramzan (M)

Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi GT Road, Phagwara144411, Punjab, India.
Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh160014, Punjab, India.

Mohd Zaheen Hassan (MZ)

Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha61441, Saudi Arabia.

Wael A Mahdi (WA)

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh11451, Saudi Arabia.

Thomas J Webster (TJ)

School of Health and Biomedical Engineering, Hebei University of Technology, Tianjin065000, China.
School of Engineering, Saveetha University, Chennai602117, India.
Materials Science Program, UFPI, Teresina64064, Brazil.

Classifications MeSH