Low-dose IL-2 reduces IL-21
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 11 2022
28 11 2022
Historique:
received:
10
04
2022
accepted:
17
10
2022
entrez:
28
11
2022
pubmed:
29
11
2022
medline:
1
12
2022
Statut:
epublish
Résumé
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples. Our results confirm that iLD-IL-2 selectively expands thymic-derived FOXP3
Identifiants
pubmed: 36443294
doi: 10.1038/s41467-022-34162-3
pii: 10.1038/s41467-022-34162-3
pmc: PMC9705541
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Interleukin-2
0
interleukin-21
MKM3CA6LT1
Banques de données
figshare
['10.6084/m9.figshare.21395214']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7324Informations de copyright
© 2022. The Author(s).
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