p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
29 11 2022
29 11 2022
Historique:
received:
30
05
2022
accepted:
16
11
2022
revised:
15
11
2022
entrez:
29
11
2022
pubmed:
30
11
2022
medline:
2
12
2022
Statut:
epublish
Résumé
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly aflatoxins. Moreover, genotoxic plant toxins including phenylpropenes are suspected human liver carcinogens. The phenylpropene methyleugenol (ME) is a constituent of essential oils in many plants and occurs in herbal medicines, food, and cosmetics. Following its uptake, ME undergoes Cytochrome P450 (CYP) and sulfotransferase 1A1 (SULT1A1)-dependent metabolic activation, giving rise to DNA damage. However, little is known about the cellular response to the induced DNA adducts. Here, we made use of different SULT1A1-proficient cell models including primary hepatocytes that were treated with 1'-hydroxymethyleugenol (OH-ME) as main phase I metabolite. Firstly, mass spectrometry showed a concentration-dependent formation of N
Identifiants
pubmed: 36446765
doi: 10.1038/s41419-022-05446-9
pii: 10.1038/s41419-022-05446-9
pmc: PMC9708695
doi:
Substances chimiques
methyleugenol
29T9VA6R7M
Tumor Suppressor Protein p53
0
DNA Adducts
0
bcl-2-Associated X Protein
0
1'-(hydroxymethyl)eugenol
DA6575YC8S
Carcinogens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1009Informations de copyright
© 2022. The Author(s).
Références
Hepatology. 2021 Jul;74(1):264-280
pubmed: 33462832
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3101-E3109
pubmed: 28351974
Toxicology. 2020 Nov;444:152566
pubmed: 32853702
Nat Cell Biol. 2000 Oct;2(10):762-5
pubmed: 11025670
Arch Toxicol. 2017 Oct;91(10):3329-3339
pubmed: 28326452
DNA Repair (Amst). 2014 Jun;18:31-43
pubmed: 24680221
Methods Mol Biol. 2017;1510:103-113
pubmed: 27761816
Toxicol Sci. 2011 Sep;123(1):103-12
pubmed: 21659616
Arch Toxicol. 2015 Oct;89(10):1829-46
pubmed: 25526924
Toxicol Pathol. 2018 Aug;46(6):706-718
pubmed: 30045675
Carcinogenesis. 2014 Apr;35(4):935-41
pubmed: 24318996
Anal Biochem. 2013 Mar 1;434(1):4-11
pubmed: 23142629
Chem Res Toxicol. 2006 Jan;19(1):111-6
pubmed: 16411663
Oncogene. 1999 Aug 19;18(33):4726-33
pubmed: 10467420
Genes Environ. 2016 Feb 07;38:1
pubmed: 27350821
Cancer Res. 1983 Mar;43(3):1124-34
pubmed: 6825084
Bioconjug Chem. 2013 Apr 17;24(4):595-603
pubmed: 23506195
Mutagenesis. 2012 Jul;27(4):453-62
pubmed: 22337896
Carcinogenesis. 1997 Sep;18(9):1775-83
pubmed: 9328175
Carcinogenesis. 2013 May;34(5):1025-30
pubmed: 23334163
Food Chem Toxicol. 2018 Jun;116(Pt B):138-146
pubmed: 29654846
Nature. 1979 Dec 6;282(5739):615-6
pubmed: 233137
Genes Dev. 2000 Jun 15;14(12):1448-59
pubmed: 10859164
Food Chem Toxicol. 2017 Aug;106(Pt B):583-594
pubmed: 27693244
Nucleic Acids Res. 2020 Feb 20;48(3):e13
pubmed: 31822921
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S89-97
pubmed: 20113858
J Agric Food Chem. 2018 Mar 14;66(10):2259-2272
pubmed: 28006900
Food Chem Toxicol. 2017 Oct;108(Pt A):267-275
pubmed: 28818686
IARC Monogr Eval Carcinog Risks Hum. 2013;101:9-549
pubmed: 24772663
World J Gastroenterol. 2016 Nov 7;22(41):9069-9095
pubmed: 27895396
Nat Rev Gastroenterol Hepatol. 2019 Oct;16(10):589-604
pubmed: 31439937
Cell Death Dis. 2020 Sep 23;11(9):787
pubmed: 32968051
Mol Cancer Ther. 2022 Jan;21(1):100-112
pubmed: 34750196
Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001008
pubmed: 20182602
Environ Mol Mutagen. 2019 Oct;60(8):752-758
pubmed: 31102418
Gastroenterology. 2020 Jul;159(1):335-349.e15
pubmed: 32247694
Nucleic Acids Res. 2006 Jul 04;34(11):3326-37
pubmed: 16820532
Mol Cancer Ther. 2016 Nov;15(11):2665-2678
pubmed: 27474153
J Clin Invest. 1997 Feb 1;99(3):403-13
pubmed: 9022073
Mutat Res. 2004 Jul 13;551(1-2):153-66
pubmed: 15225590
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8507-12
pubmed: 11438709
Nucleic Acids Res. 2016 Dec 15;44(22):10727-10743
pubmed: 27694624
Arch Toxicol. 2016 Nov;90(11):2809-2823
pubmed: 26542539
Toxicol Sci. 2012 Sep;129(1):21-34
pubmed: 22610610
J Agric Food Chem. 2000 Aug;48(8):3620-32
pubmed: 10956160
Arch Toxicol. 2015 May;89(5):797-805
pubmed: 24912782
Nucleic Acids Res. 2014 Jul;42(13):8461-72
pubmed: 24957605
Cancer Prev Res (Phila). 2015 Jan;8(1):1-8
pubmed: 25348854
Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):60-65
pubmed: 31152819
Nucleic Acids Res. 1997 Mar 1;25(5):992-4
pubmed: 9023109
Carcinogenesis. 2004 May;25(5):801-7
pubmed: 14729582
Nat Cell Biol. 2014 Jan;16(1):2-9
pubmed: 24366029
Methods Mol Biol. 2023;2589:241-252
pubmed: 36255629
Anal Chem. 2015 Jan 6;87(1):641-8
pubmed: 25423194
Nucleic Acids Res. 2016 Dec 1;44(21):10259-10276
pubmed: 27599846
Cell Death Dis. 2017 Aug 24;8(8):e3019
pubmed: 28837154