Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 11 2022
29 11 2022
Historique:
received:
01
09
2022
accepted:
22
11
2022
entrez:
29
11
2022
pubmed:
30
11
2022
medline:
2
12
2022
Statut:
epublish
Résumé
Repetitive transcranial magnetic stimulation (rTMS) induces action potentials to induce plastic changes in the brain with increasing evidence for the therapeutic importance of brain-wide functional network effects of rTMS; however, the influence of sub-action potential threshold (low-intensity; LI-) rTMS on neuronal activity is largely unknown. We investigated whether LI-rTMS modulates neuronal activity and functional connectivity and also specifically assessed modulation of parvalbumin interneuron activity. We conducted a brain-wide analysis of c-Fos, a marker for neuronal activity, in mice that received LI-rTMS to visual cortex. Mice received single or multiple sessions of excitatory 10 Hz LI-rTMS with custom rodent coils or were sham controls. We assessed changes to c-Fos positive cell densities and c-Fos/parvalbumin co-expression. Peak c-Fos expression corresponded with activity during rTMS. We also assessed functional connectivity changes using brain-wide c-Fos-based network analysis. LI-rTMS modulated c-Fos expression in cortical and subcortical regions. c-Fos density changes were most prevalent with acute stimulation, however chronic stimulation decreased parvalbumin interneuron activity, most prominently in the amygdala and striatum. LI-rTMS also increased anti-correlated functional connectivity, with the most prominent effects also in the amygdala and striatum following chronic stimulation. LI-rTMS induces changes in c-Fos expression that suggest modulation of neuronal activity and functional connectivity throughout the brain. Our results suggest that LI-rTMS promotes anticorrelated functional connectivity, possibly due to decreased parvalbumin interneuron activation induced by chronic stimulation. These changes may underpin therapeutic rTMS effects, therefore modulation of subcortical activity supports rTMS for treatment of disorders involving subcortical dysregulation.
Identifiants
pubmed: 36446821
doi: 10.1038/s41598-022-24934-8
pii: 10.1038/s41598-022-24934-8
pmc: PMC9708643
doi:
Substances chimiques
Parvalbumins
0
Antibodies
0
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20571Informations de copyright
© 2022. The Author(s).
Références
Curr Res Neurobiol. 2022 Feb 23;3:100033
pubmed: 36685761
Curr Opin Neurobiol. 2019 Oct;58:61-69
pubmed: 31336326
Sci Adv. 2020 Apr 22;6(17):eaay5333
pubmed: 32426459
Neuron. 2017 Apr 19;94(2):363-374.e4
pubmed: 28426969
Exp Brain Res. 2019 Apr;237(4):883-896
pubmed: 30649586
Cereb Cortex. 2018 May 1;28(5):1831-1845
pubmed: 29106504
Neuron. 2017 Mar 8;93(5):1165-1179.e6
pubmed: 28238546
Front Hum Neurosci. 2021 Sep 08;15:718662
pubmed: 34566602
Brain Stimul. 2019 Nov - Dec;12(6):1526-1536
pubmed: 31296402
Neuroimage. 2009 Feb 1;44(3):893-905
pubmed: 18976716
Brain Stimul. 2014 May-Jun;7(3):394-400
pubmed: 24656783
Exp Brain Res. 2008 Jun;188(2):249-61
pubmed: 18385988
Hum Brain Mapp. 2015 Jan;36(1):199-212
pubmed: 25164875
Neuroscience. 2016 Oct 29;335:64-71
pubmed: 27568058
Nature. 2007 Jan 11;445(7124):168-76
pubmed: 17151600
PLoS One. 2015 Apr 30;10(4):e0125286
pubmed: 25928647
J Psychiatr Res. 2015 May;64:9-18
pubmed: 25801734
Elife. 2015 Mar 03;4:
pubmed: 25735038
Neuroimage. 2003 Nov;20(3):1685-96
pubmed: 14642478
Hum Brain Mapp. 2021 Sep;42(13):4155-4172
pubmed: 33544411
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4367-75
pubmed: 25267639
Sci Rep. 2022 Jan 7;12(1):176
pubmed: 34997117
Nat Methods. 2019 Dec;16(12):1226-1232
pubmed: 31570887
J Neurosci. 2011 Jan 26;31(4):1193-203
pubmed: 21273404
Mol Psychiatry. 2018 Jul;23(7):1614-1625
pubmed: 28761082
Cell Rep. 2015 Jan 13;10(2):292-305
pubmed: 25558063
Clin Psychol Rev. 2015 Nov;41:61-9
pubmed: 25468571
J Neurosci. 2014 Nov 5;34(45):14890-900
pubmed: 25378156
Neuroimage. 2021 Feb 1;226:117559
pubmed: 33189929
Neurobiol Stress. 2022 May 06;18:100458
pubmed: 35586750
PLoS Comput Biol. 2013;9(1):e1002853
pubmed: 23300432
eNeuro. 2022 Mar 16;9(2):
pubmed: 35228311
Front Behav Neurosci. 2022 Sep 09;16:907707
pubmed: 36160680
Biol Psychiatry. 2012 Oct 1;72(7):595-603
pubmed: 22658708
Dev Neurobiol. 2020 Nov;80(11-12):399-410
pubmed: 33006265
Front Neural Circuits. 2016 Oct 06;10:80
pubmed: 27766073
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 1;34(7):1285-93
pubmed: 20647026
Sci Rep. 2018 Apr 11;8(1):5792
pubmed: 29643395
J Physiol. 2008 Dec 1;586(23):5717-25
pubmed: 18845611
J Neurosci. 2011 May 18;31(20):7521-6
pubmed: 21593336
Nat Neurosci. 2018 Jan;21(1):139-149
pubmed: 29203898
Dev Neurobiol. 2015 Jan;75(1):1-11
pubmed: 24962557
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Front Cell Dev Biol. 2020 May 29;8:407
pubmed: 32548122
Neuroimage. 2003 Sep;20(1):550-60
pubmed: 14527615
Neuroimage. 2017 Nov 15;162:289-296
pubmed: 28912081
Sci Rep. 2022 Feb 16;12(1):2581
pubmed: 35173179
Eur J Neurosci. 2004 Apr;19(7):1950-62
pubmed: 15078569
Brain Stimul. 2013 Jul;6(4):598-606
pubmed: 23433874
J Neurol Sci. 2018 Jan 15;384:10-14
pubmed: 29249365
Curr Opin Neurol. 2016 Dec;29(6):706-713
pubmed: 27749394
J Neurosci Methods. 2021 Aug 1;360:109261
pubmed: 34146593
J Anxiety Disord. 2016 Oct;43:1-7
pubmed: 27467027
eNeuro. 2021 Nov 4;8(6):
pubmed: 34580158
eNeuro. 2018 Feb 14;5(1):
pubmed: 29464193
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13372-7
pubmed: 11069288
J Physiol. 2022 Sep;600(17):4019-4037
pubmed: 35899578
Neural Regen Res. 2015 Mar;10(3):357-9
pubmed: 25878575
Science. 2014 Aug 29;345(6200):1054-7
pubmed: 25170153
Hippocampus. 2014 Mar;24(3):326-40
pubmed: 24174292
Restor Neurol Neurosci. 2015;33(4):521-30
pubmed: 26409410
Neurosci Lett. 2013 Mar 1;536:19-23
pubmed: 23328445
Sci Rep. 2018 Apr 30;8(1):6706
pubmed: 29712947
Neuroinformatics. 2015 Jul;13(3):353-66
pubmed: 25682754
Neural Plast. 2010;2010:139891
pubmed: 20592749
Nature. 2009 Jun 4;459(7247):698-702
pubmed: 19396159
Front Neurosci. 2020 Jun 16;14:558
pubmed: 32612497
Brain Connect. 2011;1(3):195-206
pubmed: 22433048
Eur J Neurosci. 2008 Feb;27(3):765-74
pubmed: 18279329