Optimal Management of Dysphagia in Patients with Inoperable Esophageal Cancer: Current Perspectives.

cryotherapy esophageal cancer external beam radiation therapy self-expandable metal stent

Journal

Cancer management and research
ISSN: 1179-1322
Titre abrégé: Cancer Manag Res
Pays: New Zealand
ID NLM: 101512700

Informations de publication

Date de publication:
2022
Historique:
received: 12 07 2022
accepted: 08 11 2022
entrez: 30 11 2022
pubmed: 1 12 2022
medline: 1 12 2022
Statut: epublish

Résumé

The majority of patients with esophageal cancer are diagnosed at an advanced, incurable stage. Palliation of symptoms, specifically dysphagia, is a crucial component to improve quality of life and optimize nutritional status. Despite multiple available treatment modalities, there is not one accepted or recommended to be the preferred treatment option. Palliative management is often decided by a multidisciplinary team considering factors including local availability, preference, patient life expectancy, and symptom severity. Systemic therapies such as chemotherapy are the most commonly used palliative modalities. Oncologists are most familiar with radiation for dysphagia palliation, especially for advanced metastatic cancer patients with good performance status. One common approach used by endoscopist is self-expandable metal stents. This is preferred for patients with short-term survival and poor functional status as it provides rapid relief of dysphagia. Cryotherapy is a relatively new endoscopic ablative modality and appears to be a promising option for dysphagia palliation, but more data is needed for wider adoption. This review summarizes the current literature on endoscopic and non-endoscopic treatment options for malignant dysphagia.

Identifiants

pubmed: 36448034
doi: 10.2147/CMAR.S362666
pii: 362666
pmc: PMC9701451
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

3281-3291

Informations de copyright

© 2022 Mohapatra et al.

Déclaration de conflit d'intérêts

Toufic Kachaamy: Consultant for Medtronic, Steris, Pentax, Microtech. Receives educational support from Boston Scientific and Cook. Rahul Pannala: Research funding from ERBE, USA, consulting fees from HCL technologies, personal fees from Bluestar Genomics and Nestle Health Sciences, and grants from Fractyl Labs. All other authors have no financial disclosures.

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Auteurs

Sonmoon Mohapatra (S)

Department of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, 85054, USA.

Aadhithyaraman Santharaman (A)

Department of Internal Medicine, Saint Peter's University Hospital, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ, 08901, USA.

Krista Gomez (K)

Department of Gastroenterology and Hepatology, Cancer Treatment Centers of America, Phoenix, AZ, 85338, USA.

Rahul Pannala (R)

Department of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, 85054, USA.

Toufic Kachaamy (T)

Department of Gastroenterology and Hepatology, Cancer Treatment Centers of America, Phoenix, AZ, 85338, USA.

Classifications MeSH