Cathepsin B and Muscular Strength are Independently Associated with Cognitive Control.
Cathepsin B
attentional control
cognition
electroencephalography
muscle strength
physical fitness
Journal
Brain plasticity (Amsterdam, Netherlands)
ISSN: 2213-6312
Titre abrégé: Brain Plast
Pays: Netherlands
ID NLM: 101669568
Informations de publication
Date de publication:
2022
2022
Historique:
accepted:
18
01
2022
entrez:
30
11
2022
pubmed:
1
12
2022
medline:
1
12
2022
Statut:
epublish
Résumé
Although muscular strength has been linked to greater cognitive function across different cognitive domains, the mechanism(s) through which this occurs remain(s) poorly understood. Indeed, while an emerging body of literature suggests peripheral myokines released from muscular contractions may play a role in this relationship, additional research is needed to understand this link. Accordingly, this study sought to compare the influences of a particular myokine, Cathepsin B (CTSB), and muscular strength on hippocampal-dependent relational memory and cognitive control in 40 adults (age = 50.0±7.3 yrs). Overnight fasted venous blood draws were taken to assess plasma CTSB and muscular strength was assessed as maximal isokinetic strength testing using a Biodex dynamometer. Cognitive performance was assessed using a Spatial Reconstruction Task to assess relational memory and a modified Flanker task to assess cognitive control. Neuroelectric function for cognitive control was assessed using event-related potentials (ERPs) recorded during the Flanker task. Initial bivariate correlational analyses revealed that neither sex, age, lean body mass, or muscular strength was associated with CTSB. However, CTSB was inversely associated with reaction time and fractional peak latency of the P3 component of the Flanker task. Muscular strength was also inversely associated with reaction time and positively associated with relational memory performance. However, the influence of muscular strength on relational memory did not persist following adjustment for covariates. Greater circulating CTSB was selectively associated with greater cognitive control as well as faster information processing speed. These findings are the first to link circulating CTSB to both cognitive control and neuroelectric function. Future intervention studies are needed to examine the effects of changes in muscular strength, circulating myokines, and different domains of cognitive function.
Identifiants
pubmed: 36448041
doi: 10.3233/BPL-210136
pii: BPL210136
pmc: PMC9661349
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19-33Informations de copyright
© 2022 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
None of the authors have a conflict of interest to report.
Références
Psychol Res. 2020 Jul;84(5):1167-1183
pubmed: 30627769
Arch Neurol. 2004 Apr;61(4):556-60
pubmed: 15096405
Psychol Aging. 2005 Mar;20(1):3-18
pubmed: 15769210
J Appl Gerontol. 2017 Jun;36(6):709-732
pubmed: 25948290
J Lifestyle Med. 2018 Jul;8(2):99-104
pubmed: 30474005
Sci Rep. 2019 Mar 4;9(1):3337
pubmed: 30833610
Age Ageing. 1998 Jul;27(4):469-75
pubmed: 9884004
Psychophysiology. 2020 Jul;57(7):e13425
pubmed: 31228362
Cell Metab. 2016 Aug 9;24(2):332-40
pubmed: 27345423
Nutr Neurosci. 2022 Jul;25(7):1437-1452
pubmed: 33448903
ACS Omega. 2021 Mar 31;6(14):9609-9616
pubmed: 33869941
Med Sci Sports Exerc. 2016 Nov;48(11):2082-2089
pubmed: 27327027
Front Hum Neurosci. 2014 Dec 11;8:985
pubmed: 25566019
Brain Res Rev. 2006 Aug 30;52(1):119-30
pubmed: 16490256
Med Sci Sports Exerc. 2016 Jun;48(6):1197-222
pubmed: 27182986
Am J Physiol Endocrinol Metab. 2021 May 1;320(5):E900-E913
pubmed: 33682457
J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):269-278
pubmed: 29349935
J Sports Sci. 2009 Jan 1;27(1):59-68
pubmed: 19031334
J Am Geriatr Soc. 2002 May;50(5):889-96
pubmed: 12028177
PM R. 2011 May;3(5):472-9
pubmed: 21570036
Brain Dev. 2009 Jan;31(1):52-7
pubmed: 18723303
Brain Behav Immun. 2012 Jul;26(5):811-9
pubmed: 22172477
Prev Med Rep. 2021 Jul 16;23:101496
pubmed: 34377632
Psychosom Med. 2010 Apr;72(3):239-52
pubmed: 20223924
Neuroscience. 2020 Jun 15;437:242-255
pubmed: 32482330
Neurosci Biobehav Rev. 2018 Jan;84:225-244
pubmed: 29203421
Ageing Res Rev. 2016 Dec;32:22-37
pubmed: 27125852
J Neuropsychol. 2014 Sep;8(2):186-98
pubmed: 23647550
Gerontologist. 2007 Jun;47(3):307-22
pubmed: 17565095
J Appl Physiol (1985). 2004 Nov;97(5):1693-701
pubmed: 15180971
Annu Rev Psychol. 2013;64:135-68
pubmed: 23020641
Hum Brain Mapp. 2010 Jul;31(7):1052-64
pubmed: 19998366
PLoS One. 2021 Jun 4;16(6):e0251907
pubmed: 34086693
Psychophysiology. 2021 May;58(5):e13799
pubmed: 33655551
Sci Rep. 2020 Jun 25;10(1):10367
pubmed: 32587294
Front Hum Neurosci. 2014 Apr 14;8:213
pubmed: 24782741
J Alzheimers Dis. 2010;19(1):311-23
pubmed: 20061647
Physiol Rep. 2019 Jun;7(11):e14140
pubmed: 31175708
Alzheimers Dement. 2007 Apr;3(2):98-108
pubmed: 18379636
Nutrients. 2019 Apr 02;11(4):
pubmed: 30986960
J Am Geriatr Soc. 2003 Apr;51(4):459-65
pubmed: 12657064
Clin Physiol Funct Imaging. 2018 Jan 24;:
pubmed: 29368393
Br J Sports Med. 2003 Dec;37(6):521-8
pubmed: 14665592
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20906-11
pubmed: 19948959
Eur J Neurosci. 2005 Jan;21(1):1-14
pubmed: 15654838
Springerplus. 2015 Sep 28;4:557
pubmed: 26435903
J Gerontol B Psychol Sci Soc Sci. 2002 Mar;57(2):P163-72
pubmed: 11867664
Eur Rev Aging Phys Act. 2019 Jul 10;16:10
pubmed: 31333805
Front Endocrinol (Lausanne). 2021 May 20;12:660181
pubmed: 34093436
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Front Hum Neurosci. 2015 Feb 18;9:66
pubmed: 25741267
Neuron. 2004 Sep 30;44(1):109-20
pubmed: 15450164
Front Psychol. 2016 Jul 27;7:1124
pubmed: 27512383
Endocr Rev. 2020 Aug 1;41(4):
pubmed: 32393961
Neuroscience. 2012 Jan 27;202:309-17
pubmed: 22155655
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499
Front Neurosci. 2018 Feb 07;12:52
pubmed: 29467613