The combination of autism and exceptional cognitive ability is associated with suicidal ideation.
Autism
Cognition
Genetics
Intelligence
Mental health
Polygenic scores
Psychiatry
Suicide
Twice-exceptional
Journal
Neurobiology of learning and memory
ISSN: 1095-9564
Titre abrégé: Neurobiol Learn Mem
Pays: United States
ID NLM: 9508166
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
15
02
2022
revised:
04
10
2022
accepted:
31
10
2022
pmc-release:
01
01
2024
pubmed:
1
12
2022
medline:
3
1
2023
entrez:
30
11
2022
Statut:
ppublish
Résumé
Autism with co-occurring exceptional cognitive ability is often accompanied by severe internalizing symptoms and feelings of inadequacy. Whether cognitive ability also translates into greater risk for suicidal ideation is unclear. To investigate this urgent question, we examined two samples of high-ability autistic individuals for factors that were predictive of suicidal ideation. In the first sample (N = 1,074 individuals seen at a clinic specializing in gifted/talented youth), we observed a striking excess of parent-reported suicidal ideation in autistic individuals with IQ ≥ 120 (Odds Ratio = 5.9, p=0.0007). In a separate sample of SPARK participants, we confirmed higher rates of suicidal thoughts compared to non-autistic children from the ABCD cohort (combined N = 16,049, Odds Ratio = 6.8, p<2.2e-16), and further that autistic children with suicidal thoughts had significantly higher cognitive ability (p<2.2e-16) than those without. Elevated polygenic scores (PGS) for cognitive performance were associated with increased suicidal thoughts (N = 1,983, Z=2.16,p=0.03), with PGS for educational attainment trending in the same direction (Z=1.4,p=0.17). Notably, similar results were found in parents of these autistic youth, where higher PGS for educational attainment was associated with increasing thoughts of suicide (N = 736, Z=2.28,p=0.02). Taken together, these results suggest that on a phenotypic and genetic level, increasing cognitive ability is an unexpected risk factor for suicidal ideation in individuals diagnosed with, or at risk for autism.
Identifiants
pubmed: 36450307
pii: S1074-7427(22)00122-8
doi: 10.1016/j.nlm.2022.107698
pmc: PMC10088461
mid: NIHMS1887014
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107698Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103556
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014489
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG012697
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008629
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Psychoneuroendocrinology. 2016 Jan;63:370-9
pubmed: 26555430
Autism. 2022 Feb;26(2):552-559
pubmed: 34420418
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
Dev Cogn Neurosci. 2018 Aug;32:80-96
pubmed: 29559216
Gigascience. 2021 Jun 29;10(6):
pubmed: 34184051
Mol Autism. 2018 Jul 31;9:42
pubmed: 30083306
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
J Autism Dev Disord. 2012 Jan;42(1):75-81
pubmed: 21424864
Neuron. 2018 Feb 7;97(3):488-493
pubmed: 29420931
Nature. 2021 Feb;590(7845):290-299
pubmed: 33568819
Mol Psychiatry. 2021 Dec;26(12):7436-7445
pubmed: 34168285
BMJ. 2010 Jun 03;340:c2506
pubmed: 20522657
JAMA Netw Open. 2021 Jan 4;4(1):e2033565
pubmed: 33433599
Autism Res. 2022 Jan;15(1):156-170
pubmed: 34636158
Autism Res. 2019 Apr;12(4):658-666
pubmed: 30663277
Brief Bioinform. 2013 Mar;14(2):144-61
pubmed: 22908213
Clin Psychol Rev. 2021 Nov;89:102080
pubmed: 34563942
Nat Genet. 2019 Mar;51(3):431-444
pubmed: 30804558
Psychol Sci. 2016 Sep;27(9):1249-65
pubmed: 27481911
Psychol Res Behav Manag. 2014 Apr 12;7:125-36
pubmed: 24748827
Gen Hosp Psychiatry. 2013 Jan-Feb;35(1):50-3
pubmed: 23141028
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Curr Top Behav Neurosci. 2020;46:63-78
pubmed: 32794081
J Abnorm Child Psychol. 2019 Jan;47(1):165-175
pubmed: 29497980
Bioinformatics. 2021 Apr 1;36(22-23):5424-5431
pubmed: 33326037
Neurology. 2013 Mar 12;80(11 Suppl 3):S54-64
pubmed: 23479546
J Autism Dev Disord. 2020 Dec;50(12):4344-4355
pubmed: 32270386
Gigascience. 2021 Feb 16;10(2):
pubmed: 33590861
Clin Psychol Rev. 2022 Apr;93:102144
pubmed: 35290800
Depress Anxiety. 2018 Jul;35(7):648-657
pubmed: 29659141
J Child Psychol Psychiatry. 2019 Jan;60(1):102-110
pubmed: 29582425
Mol Psychiatry. 2021 May;26(5):1670-1684
pubmed: 31659270
Nat Neurosci. 2019 Mar;22(3):343-352
pubmed: 30718901
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
Bioinformatics. 2018 Aug 15;34(16):2781-2787
pubmed: 29617937
Br J Psychiatry. 2016 Mar;208(3):232-8
pubmed: 26541693
MMWR Surveill Summ. 2021 Dec 03;70(11):1-16
pubmed: 34855725
Neurobiol Learn Mem. 2022 Nov;195:107684
pubmed: 36174887
Mol Autism. 2021 Feb 16;12(1):13
pubmed: 33593423
JAMA Psychiatry. 2019 Oct 1;76(10):1035-1043
pubmed: 31314057
Acta Psychiatr Scand. 2008 Aug;118(2):99-105
pubmed: 18331576
Acta Psychiatr Scand. 2018 Apr;137(4):277-286
pubmed: 29114860
Nat Genet. 2021 Jun;53(6):817-829
pubmed: 34002096