Investigating longitudinal associations of hair cortisol and cortisone with cognitive functioning and dementia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 11 2022
30 11 2022
Historique:
received:
28
07
2022
accepted:
25
11
2022
entrez:
30
11
2022
pubmed:
1
12
2022
medline:
3
12
2022
Statut:
epublish
Résumé
We rigorously investigated potential longitudinal associations of hair cortisol and cortisone with verbal memory, time orientation, and dementia, adjusting for sociodemographic and health confounders. Data from the English Longitudinal Study of Ageing wave 6-9 (6-year follow-up, covering 4399 persons aged 50+) were analysed using linear random effects and cox regression models. In unadjusted models, hair cortisol was associated with worsened verbal memory (β 0.19; SE 0.08), but not with time orientation (β 0.02; SE 0.01), or dementia (β 0.07; SE 0.16). Hair cortisone was associated with worsened verbal memory (β 0.74; SE 0.14) and time orientation (β 0.06; SE 0.02), but not with dementia (β 0.47; SE 0.28). However, in the fully adjusted models, neither hair cortisol nor cortisone was associated with verbal memory, time orientation, or dementia. Consistent with prior studies, we found that more advanced age was associated with worsened verbal memory (β 0.15; SE 0.01), time orientation (β 0.01; SE 0.00), and dementia risk (β 0.11; SE 0.02). Our rigorous analyses did not detect robust associations of neither hair cortisol nor cortisone with cognitive functioning or dementia across 6 years. More detailed insights into potential mechanisms are discussed.
Identifiants
pubmed: 36450857
doi: 10.1038/s41598-022-25143-z
pii: 10.1038/s41598-022-25143-z
pmc: PMC9712516
doi:
Substances chimiques
Cortisone
V27W9254FZ
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
20642Subventions
Organisme : NIA NIH HHS
ID : R01 AG030153
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG043052
Pays : United States
Organisme : NIA NIH HHS
ID : RC2 AG036619
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
J Am Geriatr Soc. 2018 Sep;66(9):1670-1675
pubmed: 29508385
Stress. 2012 Nov;15(6):578-88
pubmed: 22356099
Ageing Res Rev. 2020 Dec;64:101171
pubmed: 32971258
J Aging Res. 2013;2013:657508
pubmed: 24102028
Psychoneuroendocrinology. 2011 Aug;36(7):1040-52
pubmed: 21295410
Psychoneuroendocrinology. 2014 Jun;44:100-11
pubmed: 24767624
Sci Rep. 2019 Dec 23;9(1):19698
pubmed: 31873134
Psychol Med. 2010 Jun;40(6):1039-49
pubmed: 19814852
Cochrane Database Syst Rev. 2014 Apr 10;(4):CD010079
pubmed: 24719028
Obesity (Silver Spring). 2017 Mar;25(3):539-544
pubmed: 28229550
Neurobiol Aging. 2014 Oct;35(10):2239-45
pubmed: 24735831
Arch Gen Psychiatry. 2007 Jul;64(7):810-8
pubmed: 17606815
JAMA Netw Open. 2020 Sep 1;3(9):e2013573
pubmed: 32955572
Psychoneuroendocrinology. 2017 Apr;78:68-75
pubmed: 28171850
Psychoneuroendocrinology. 2009 Aug;34(7):1050-5
pubmed: 19272716
Stress. 2021 Nov;24(6):772-779
pubmed: 33913374
J Alzheimers Dis. 2017;58(1):99-108
pubmed: 28387667
Physiol Rev. 2013 Jul;93(3):1139-206
pubmed: 23899562
Psychoneuroendocrinology. 2012 May;37(5):602-10
pubmed: 21917384
Psychoneuroendocrinology. 2022 Feb;136:105619
pubmed: 34896739
J Am Geriatr Soc. 2000 Dec;48(12):1655-8
pubmed: 11129757
Neurobiol Aging. 2011 Jul;32(7):1304-19
pubmed: 19716631
Eur J Neurosci. 2017 Feb;45(4):478-489
pubmed: 27862513
Lancet. 2007 Oct 20;370(9596):1453-7
pubmed: 18064739
Dement Geriatr Cogn Dis Extra. 2014 Oct 14;4(3):375-84
pubmed: 25473404
Psychoneuroendocrinology. 2014 Jan;39:132-140
pubmed: 24275012
Diabetologia. 2018 Apr;61(4):839-848
pubmed: 29368156
J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):257-265
pubmed: 30412218
Psychoneuroendocrinology. 2016 May;67:100-3
pubmed: 26881835
J Alzheimers Dis. 2011;25(4):671-7
pubmed: 21483093
BMC Geriatr. 2019 Dec 2;19(1):337
pubmed: 31791248
J Clin Endocrinol Metab. 1998 Oct;83(10):3487-92
pubmed: 9768651
Int J Epidemiol. 2019 Dec 1;48(6):1925-1936
pubmed: 31280313
Stress. 2018 Jan;21(1):43-50
pubmed: 29073819
Neurology. 2020 Jan 14;94(2):e133-e141
pubmed: 31831603
Psychiatry Investig. 2012 Mar;9(1):8-16
pubmed: 22396679
Neurology. 2015 Sep 15;85(11):976-83
pubmed: 26291281
Lancet Public Health. 2021 Feb;6(2):e106-e115
pubmed: 33516287
Eur J Endocrinol. 2017 Jun;176(6):695-703
pubmed: 28289104
Psychoneuroendocrinology. 2020 Nov;121:104810
pubmed: 32739745
Expert Rev Endocrinol Metab. 2018 Sep;13(5):225-231
pubmed: 30234410
J Gerontol B Psychol Sci Soc Sci. 2020 Jan 1;75(1):114-124
pubmed: 28658937
Psychoneuroendocrinology. 2017 Mar;77:261-274
pubmed: 28135674