A dual tracer [
Brain
Brain metabolism
Conjunction analysis
Microglia
Micropet imaging
Murine endotoxemia
Neuroinflammation
[11C]PBR28
[18F]FDG
Journal
Bioelectronic medicine
ISSN: 2332-8886
Titre abrégé: Bioelectron Med
Pays: England
ID NLM: 101660849
Informations de publication
Date de publication:
30 Nov 2022
30 Nov 2022
Historique:
received:
18
10
2022
accepted:
09
11
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
2
12
2022
Statut:
epublish
Résumé
Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments. However, non-invasive evaluation of these alterations remains a challenge. Here, we studied the utility of a micro positron emission tomography (microPET) dual tracer ([ There were significant increases in [ Together, these findings demonstrate the applicability of [
Sections du résumé
BACKGROUND
BACKGROUND
Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments. However, non-invasive evaluation of these alterations remains a challenge.
METHODS
METHODS
Here, we studied the utility of a micro positron emission tomography (microPET) dual tracer ([
RESULTS
RESULTS
There were significant increases in [
CONCLUSIONS
CONCLUSIONS
Together, these findings demonstrate the applicability of [
Identifiants
pubmed: 36451231
doi: 10.1186/s42234-022-00101-2
pii: 10.1186/s42234-022-00101-2
pmc: PMC9710165
doi:
Types de publication
Journal Article
Langues
eng
Pagination
18Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118182
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
J Neuroinflammation. 2004 Jul 30;1(1):14
pubmed: 15285801
J Neuroimmune Pharmacol. 2006 Jun;1(2):127-37
pubmed: 18040779
Mol Med. 2003 May-Aug;9(5-8):125-34
pubmed: 14571320
J Nucl Med. 2016 Jun;57(6):954-60
pubmed: 26912428
Front Immunol. 2017 Dec 15;8:1673
pubmed: 29326685
Nat Rev Neurol. 2021 Mar;17(3):157-172
pubmed: 33318676
Glia. 2020 Feb;68(2):280-297
pubmed: 31479168
Neuroimage. 2012 Oct 15;63(1):232-9
pubmed: 22776451
Mol Neurobiol. 2018 Mar;55(3):2685-2695
pubmed: 28421541
Neurobiol Aging. 2012 Sep;33(9):1995-2005
pubmed: 22079157
Neurochem Int. 1996 Jul;29(1):25-35
pubmed: 8808786
Ann Neurol. 2018 Jun;83(6):1186-1197
pubmed: 29740862
J Neuroinflammation. 2015 Jun 06;12:114
pubmed: 26048578
Neurobiol Dis. 2015 Jan;73:399-406
pubmed: 25447231
Ann N Y Acad Sci. 2019 Feb;1437(1):43-56
pubmed: 30499145
Neuroimage. 2003 Nov;20(3):1894-8
pubmed: 14642499
Clin Dev Immunol. 2013;2013:623036
pubmed: 24027590
Neuron. 2022 Nov 2;110(21):3627-3644
pubmed: 36174571
Int J Mol Sci. 2018 Sep 11;19(9):
pubmed: 30208620
J Nucl Med. 2008 Mar;49(3):390-8
pubmed: 18287270
Nat Neurosci. 2007 Nov;10(11):1387-94
pubmed: 17965659
Sci Transl Med. 2021 Oct 13;13(615):eabe5640
pubmed: 34644146
Nat Commun. 2022 Nov 2;13(1):6581
pubmed: 36323693
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
J Neuroinflammation. 2016 Aug 31;13(1):221
pubmed: 27578213
Cell Metab. 2019 Sep 3;30(3):493-507.e6
pubmed: 31257151
Pharmacol Ther. 2008 Apr;118(1):1-17
pubmed: 18374421
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Mol Med. 2015 Mar 11;20:601-11
pubmed: 25299421
Nat Neurosci. 2017 Mar;20(3):393-395
pubmed: 28135241
EJNMMI Res. 2014 Dec;4(1):20
pubmed: 26055934
J Nucl Med. 2008 Mar;49(3):480-508
pubmed: 18287273
Glia. 2007 Apr 1;55(5):453-62
pubmed: 17203472
Immunol Res. 2015 Dec;63(1-3):38-57
pubmed: 26512000
Brain Behav Immun. 2011 Feb;25(2):181-213
pubmed: 20970492
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Neurochem Int. 2019 Nov;130:104331
pubmed: 30423423
J Cereb Blood Flow Metab. 2015 Aug;35(8):1331-8
pubmed: 25833342
JAMA Neurol. 2015 Aug;72(8):882-8
pubmed: 26052981
J Neurosci. 2012 Aug 8;32(32):10809-18
pubmed: 22875916
J Nucl Med. 2007 Dec;48(12):2072-9
pubmed: 18006619
J Cereb Blood Flow Metab. 2003 Feb;23(2):137-49
pubmed: 12571445
Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):525-34
pubmed: 25550206
Neuroscience. 2005;135(4):1203-15
pubmed: 16165303
J Cereb Blood Flow Metab. 2014 Aug;34(8):1315-20
pubmed: 24824914
Annu Rev Immunol. 2018 Apr 26;36:783-812
pubmed: 29677475
Neurobiol Dis. 2009 Jan;33(1):20-7
pubmed: 18930824
Glia. 2016 Jun;64(6):993-1006
pubmed: 26959396
Arch Neurol. 2009 Oct;66(10):1288-9
pubmed: 19822787
JCI Insight. 2017 May 4;2(9):
pubmed: 28469088
Pharmacol Ther. 2011 May;130(2):226-38
pubmed: 21334376
J Nucl Med. 2007 Feb;48(2):277-87
pubmed: 17268026
Nat Rev Drug Discov. 2005 Oct;4(10):854-65
pubmed: 16224456
Neurology. 2021 Mar 23;96(12):e1608-e1619
pubmed: 33514647
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):316-21
pubmed: 9419373
Neuroscience. 1999;93(4):1449-64
pubmed: 10501470
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12468-73
pubmed: 26385967
Front Immunol. 2020 Mar 20;11:493
pubmed: 32265936
Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29803-29810
pubmed: 33168718
Crit Care Med. 1990 Aug;18(8):801-6
pubmed: 2379391
Trends Immunol. 2020 Sep;41(9):805-819
pubmed: 32800705
J Neurochem. 2021 Sep;158(6):1359-1380
pubmed: 33219523
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6638-43
pubmed: 21464304
Nat Rev Neurol. 2012 Oct;8(10):557-66
pubmed: 22986430