Identification of fungi causing humidifier lung: 2 rare cases and a review of the literature.
Air conditioner
Fungi
Humidifier lung
Hypersensitivity pneumonitis
Mycoses
Journal
Asia Pacific allergy
ISSN: 2233-8276
Titre abrégé: Asia Pac Allergy
Pays: Netherlands
ID NLM: 101561954
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
29
06
2022
accepted:
26
10
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
2
12
2022
Statut:
epublish
Résumé
Humidifier lung (HL) is a hypersensitivity pneumonitis resulting from exposure to humidifiers, with fungi from the humidifier as one of the etiologic agents. However, identification of the fungal species responsible for each case can be challenging because of difficulties in culturing fungi, their accurate identification, and interpreting the results of specific serum IgG testing. To clarify the best way to determine the causative fungal species of each HL case. We report 2 cases with HL in which rare fungi were identified as causative agents. In addition, we searched MEDLINE for previous publications on HL caused by fungi and performed a literature review focusing on clinical testing for the determination of causal fungal species. In our 2 cases, we identified We recommend performing culture of fungi from HW and specific serum IgG testing for the accurate determination of the causative fungal species in HL, and concordance between them serves as a rationale for the determination of causative fungal species.
Sections du résumé
Background
UNASSIGNED
Humidifier lung (HL) is a hypersensitivity pneumonitis resulting from exposure to humidifiers, with fungi from the humidifier as one of the etiologic agents. However, identification of the fungal species responsible for each case can be challenging because of difficulties in culturing fungi, their accurate identification, and interpreting the results of specific serum IgG testing.
Objective
UNASSIGNED
To clarify the best way to determine the causative fungal species of each HL case.
Methods
UNASSIGNED
We report 2 cases with HL in which rare fungi were identified as causative agents. In addition, we searched MEDLINE for previous publications on HL caused by fungi and performed a literature review focusing on clinical testing for the determination of causal fungal species.
Results
UNASSIGNED
In our 2 cases, we identified
Conclusion
UNASSIGNED
We recommend performing culture of fungi from HW and specific serum IgG testing for the accurate determination of the causative fungal species in HL, and concordance between them serves as a rationale for the determination of causative fungal species.
Identifiants
pubmed: 36452018
doi: 10.5415/apallergy.2022.12.e43
pmc: PMC9669469
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e43Informations de copyright
Copyright © 2022. Asia Pacific Association of Allergy, Asthma and Clinical Immunology.
Déclaration de conflit d'intérêts
Conflict of Interest: YF received contracts from any entity from Novartis Pharma KK. YF received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Thermo Fisher Diagnostics KK, Torii Pharmaceutical Co, Ltd, Novartis Pharma KK, Kyorin Pharmaceutical Co, Ltd, Sanofi KK, and Taiho Pharmaceutical Co, Ltd. YK received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi KK, GlaxoSmithKline KK, and AstraZeneca KK. MT (To National Hospital Organization Sagamihara National Hospital) received grants or contracts from any entity GlaxoSmithKline K.K, Sanofi, and Novartis. Received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from GlaxoSmithKline K.K, Sanofi, and Novartis. JA received grants or contracts from any entity from The Uehara Memorial Foundation, Japanese Respiratory Foundation, Grant-in-Aid for Scientific Research (KAKENHI), Philips K.K., Boehringer-ingelheim. JA received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi K.K., Kyorin Pharmaceutical Co, Ltd, GlaxoSmithKline K.K., AstraZeneca K.K., Boehringer-ingelheim. JA served participation on a Data Safety Monitoring Board or Advisory Board from Janssen Pharmaceutical K.K. JA received receipt of equipment, materials, drugs, medical writing, gifts or other services from Kowa Company, Ltd. KR, KS, AS, YH, KW, KK (Kazuyoshi Kuwano), and KK (Katsuhiko Kamei) have stated that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this publication.
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