Modeling extracellular matrix through histo-molecular gradient in NSCLC for clinical decisions.
WNT signaling pathway
epithelial-to-mesenchymal transition
extracellular matrix
glycosaminoglycans
lung cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
09
2022
accepted:
27
10
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
2
12
2022
Statut:
epublish
Résumé
Lung cancer still represents a global health problem, being the main type of tumor responsible for cancer deaths. In this context, the tumor microenvironment, and the extracellular matrix (ECM) pose as extremely relevant. Thus, this study aimed to explore the prognostic value of epithelial-to-mesenchymal transition (EMT), Wnt signaling, and ECM proteins expression in patients with non-small-cell lung carcinoma (NSCLC) with clinical stages I-IIIA. For that, we used 120 tissue sections from patients and evaluated the immunohistochemical, immunofluorescence, and transmission electron microscopy (TEM) to each of these markers. We also used
Identifiants
pubmed: 36452484
doi: 10.3389/fonc.2022.1042766
pmc: PMC9703002
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1042766Informations de copyright
Copyright © 2022 Baldavira, Prieto, Machado-Rugolo, de Miranda, de Oliveira, Velosa, Teodoro, Ab’Saber, Takagaki and Capelozzi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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